Noscapine / TumCG Cancer Research Results

Nos, Noscapine: Click to Expand ⟱

Features:

Noscapine is a natural product. It is an isoquinoline alkaloid derived from the opium poppy (Papaver somniferum), although unlike some opium alkaloids, it does not have narcotic effects.
-Historically, it has been used as an antitussive (cough suppressant) due to its antitussive properties without causing the sedation associated with opiates.

Pathways:
-Mitochondrial stress, release of cytochrome c, and activation of caspases (such as caspase-3), leading to cellular apoptosis.
-Inhibit angiogenesis
-Interfere with the NF-κB signaling pathway

-Noscapine can enhance the effects of traditional chemotherapeutics when used in combination. It may help overcome drug resistance by modulating cell cycle regulators and apoptosis-related proteins.

TumCG, Tumor cell growth: Click to Expand ⟱

Source:

Type:

Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).

Scientific Papers found: Click to Expand⟱

1911-

Nos,

Noscapine inhibits tumor growth in TMZ-resistant gliomas

in-vitro,

GBM,

in-vivo,

GBM,

animals

TumCG↓, TumCI↓, OS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Migration ⓘ

TumCI↓, 1,

Functional Outcomes ⓘ

OS↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TumCG, Tumor cell growth

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells