urea / TumMeta Cancer Research Results

urea, urea: Click to Expand ⟱
Features:
Urea is a small, organic molecule (chemical formula: CO(NH₂)₂) that is the primary nitrogen-containing waste product in mammals. It is produced in the liver through the urea cycle, a metabolic pathway that converts toxic ammonia (a byproduct of protein metabolism) into urea, which is then excreted in urine by the kidneys.

-Urea can act as a solubilizing agent for certain drugs, especially those that might benefit from improved solubility in aqueous environments.
-Presence of urea (as a carrier) increased the aqueous solubility of capsaicin by 3.6-fold compared to pure capsaicin
-Urea disrupts the hydrogen bonding within the water molecules which allows hydrophobic solutes to become solvated in water

-In dermatology, urea is commonly present in creams, lotions, and ointments not only for its moisturizing effects but also for its ability to enhance the absorption of other therapeutic agents.
TumMeta, Cancer Metastasis: Click to Expand ⟱
Source:
Type:
Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EPR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 1,   Half-Life∅, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:304  Target#:604  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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