Pachymic acid / mtDam Cancer Research Results

PA, Pachymic acid: Click to Expand ⟱
Features:
Pachymic acid is a lanostane-type triterpenoid predominantly extracted from the sclerotium of the fungus Poria cocos (also known as Fu Ling in Traditional Chinese Medicine).

Pachymic acid (PA) is a triterpene found in Poria, and molecular docking revealed that PA has a much higher affinity for HK II than G6P (molecular docking scores of 8.18 and 5.31, respectively)
mtDam, mitochondrial damage: Click to Expand ⟱
Source:
Type:
Mitochondrial damage can lead to a shift from oxidative phosphorylation to glycolysis, a process known as the Warburg effect. This shift can provide cancer cells with a selective advantage, allowing them to grow and proliferate more rapidly.
Mitochondrial Damage can also lead to cell death of cancer cells.
Scientific Papers found: Click to Expand⟱
2452- PA,    Targeting Pyruvate Kinase M2 and Hexokinase II, Pachymic Acid Impairs Glucose Metabolism and Induces Mitochondrial Apoptosis
- in-vitro, BC, SkBr3
HK2↓, GlucoseCon↓, lactateProd↓, mtDam↑, ATP↓, ROS↑, PKM2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PKM2↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: mtDam, mitochondrial damage
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:323  Target#:614  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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