triptolide Cancer Research Results

Trip, triptolide: Click to Expand ⟱
Features:
Triptolide is a diterpenoid triepoxide primarily isolated from the traditional Chinese medicinal plant Tripterygium wilfordii Hook F (commonly known as Thunder God Vine).

Pathways:
-Activation of caspases (key executioners of apoptosis)
-Disruption of mitochondrial membrane potential
-Cell Cycle Arrest
-Suppresses expression of c-myc and mitochondrial hexokinase II (HK-II) in cancer cells
Scientific Papers found: Click to Expand⟱
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT/SLC7A11↓, ROS↑, eff↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT/SLC7A11↓, eff↑,
7404- Trip,    Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug
- in-vitro, BC, MCF7
tumCV↓, selectivity↑, DNAdam↑, ROS↑, *ROS∅, Dose↓, TumCG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↑, 2,   xCT/SLC7A11↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,  

Cell Death(tgid=5) ⓘ

BAD↑, 1,   BAX↑, 1,   Casp3↑, 1,   GSDME-N↑, 1,   Pyro↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,   eff↑, 2,   selectivity↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS∅, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:324  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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