triptolide / Dose Cancer Research Results

Trip, triptolide: Click to Expand ⟱
Features:
Triptolide is a diterpenoid triepoxide primarily isolated from the traditional Chinese medicinal plant Tripterygium wilfordii Hook F (commonly known as Thunder God Vine).

Pathways:
-Activation of caspases (key executioners of apoptosis)
-Disruption of mitochondrial membrane potential
-Cell Cycle Arrest
-Suppresses expression of c-myc and mitochondrial hexokinase II (HK-II) in cancer cells
Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
Scientific Papers found: Click to Expand⟱
7404- Trip,    Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug
- in-vitro, BC, MCF7
tumCV↓, selectivity↑, DNAdam↑, ROS↑, *ROS∅, Dose↓, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,   selectivity↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Dose, Dosage
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:324  Target#:1114  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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