Salvia officinalis / angioG Cancer Research Results

Sage, Salvia officinalis: Click to Expand ⟱
Features:
Salvia officinalis(common sage) has been studied for its potential therapeutic effects in Alzheimer's disease (AD) and cancer due to its antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.

Salvia officinalis — AD relevance: Sage has human clinical signals for cognition/AD, plausibly via cholinesterase inhibition plus anti-inflammatory/antioxidant support. Essential-oil chemotype matters for safety (thujone exposure).

Primary mechanisms (conceptual rank):
1) ↑ Cholinergic tone (AChE/BChE inhibition; symptomatic cognitive support)AChE ↓ → ACh ↑ (symptomatic cognitive enhancement)
2) ↓ Neuroinflammation (NF-κB/cytokine tone; model-supported)
3) ↓ Oxidative stress (↓ ROS/lipid peroxidation; stress-defense support)
4) Secondary network/synaptic efficiency effects (chronic adaptation)

Bioavailability / PK relevance: Oral leaf extracts used in trials; effects are typically over weeks–months. Avoid equating leaf extract with essential oil dosing due to thujone-associated neurotoxicity risk.

Clinical evidence status: Small double-blind RCT in mild–moderate AD (extract vs placebo) and additional placebo-controlled cognitive studies in non-AD populations; evidence is supportive but not definitive/disease-modifying.

-Sage contains compounds (e.g., rosmarinic acid, luteolin, carnosic acid) that inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).This enhances acetylcholine levels, supporting memory and cognition — similar to drugs like donepezil.
-High in phenolic compounds (e.g., flavonoids, diterpenes) that scavenge reactive oxygen species (ROS).

-High doses of thujone (a compound in some sage oils) may be neurotoxic or hepatotoxic.

Salvia officinalis — AD / Neurodegeneration Pathway Map

RankPathway / AxisCellsTSFPrimary EffectNotes / Interpretation
1 AChE ↓ → ACh ↑ (cholinergic synapse) ACh ↑ (via AChE inhibition) P/R Improved synaptic cholinergic transmission Extract inhibits acetylcholinesterase → reduced ACh breakdown → increased synaptic ACh. Symptomatic mechanism analogous to donepezil-class drugs.
2Neuroinflammation (NF-κB / cytokines) ↓R/G Reduced inflammatory stress Extracts show anti-inflammatory signaling in cell/biochemical models; relevance to AD progression is supportive.
3ROS / lipid peroxidation ↓P/R Oxidative burden reduction Phenolics/diterpenes contribute to antioxidant effects; typically requires sustained intake for tissue adaptation.
4NRF2 antioxidant-response program ↔ / ↑ (context-dependent)R/G Stress-defense regulation Consider as a supportive axis; not always directly measured in human cognition trials.
5Ca²⁺ excitotoxicity interplay ↔P/R Not primary More relevant to essential-oil neurotoxicity discussions than leaf-extract cognition trials; include only with explicit Ca²⁺ endpoints.
6Aβ / tau-associated pathology ↔ (limited human evidence)G Not established clinically Any anti-amyloid/tau claims are largely preclinical; avoid over-weighting without biomarker-confirmed replication.
7Clinical Translation Constraint ↓ (constraint)— Safety + product variability Essential oil/thujone can be pro-convulsant; regulators specify limits for thujone exposure in herbal products. Extract standardization and duration (weeks–months) matter.

TSF legend: P: 0–30 min; R: 30 min–3 hr; G: >3 hr
angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
Scientific Papers found: Click to Expand⟱
3639- Sage,    Pharmacological properties of Salvia officinalis and its components
- Review, AD, NA - Review, Var, NA
AntiCan↑, *Inflam↓, *antiOx↑, *cognitive↑, *memory↑, *LDL↓, TumCG↓, MAPK↓, ROS↓, NF-kB↓, COX2↓, angioG↓, *AST↓, *ALAT?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT?, 1,   LDL↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Clinical Biomarkers ⓘ

ALAT?, 1,   AST↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: angioG, angiogenesis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:338  Target#:447  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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