Vitamin B6,pyridoxine / SAM-e Cancer Research Results

VitB6, Vitamin B6,pyridoxine: Click to Expand ⟱

Features:

Vitamin B6 (pyridoxine) has been studied in relation to Alzheimer’s disease (AD) due to its role in brain health, neurotransmitter synthesis, and homocysteine metabolism.

Biological Role of Vitamin B6
-can act as a potent antioxidant 
-Essential for the production of serotonin, dopamine, GABA, and norepinephrine.
-Homocysteine regulation: B6 is a cofactor in the conversion of homocysteine to cysteine.
    Elevated homocysteine levels are linked to increased AD risk and brain atrophy.
-Anti-inflammatory effects: B6 may modulate inflammation, a key factor in neurodegeneration.
-Myelin and cognitive function: Involved in myelin formation and synaptic plasticity.
-higher vitamin B6 intakes have been associated with greater grey matter volume

Cognitive support / Homocysteine lowering	10–50 mg/day	Often combined with B12 and folate

SAM-e, S-adenosylmethionine: Click to Expand ⟱

Source:

Type:

S-adenosylmethionine (SAM-e) is a naturally occurring compound that plays a crucial role in various cellular processes, including methylation, gene expression, and cell growth. SAM-e has been studied for its potential anti-cancer effects, and some research suggests that it may have a role in cancer prevention and treatment.
Properties:
-Inhibition of cancer cell growth
-Induction of apoptosis
-Inhibition of angiogenesis
-Modulation of epigenetic marks: SAM-e is involved in the regulation of epigenetic marks, such as DNA methylation and histone modification
-Antioxidant and anti-inflammatory effects

SAM-e expression decreased in: Liver, Breast, CRC, prostate, GC, ESo, Pancreatic
SAM-e expressing is increased in: Lung, Pancreatic, Ovarian, Melanoma, Thyroid, Renal GBM

Scientific Papers found: Click to Expand⟱

4053-

VitB12,

VitB6,

FA,

Vitamins in Alzheimer’s Disease—Review of the Latest Reports

Review,

AD,

*cognitive↑, *homoC↓, *SAM-e↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

SAM-e↓, 1,

Core Metabolism/Glycolysis ⓘ

homoC↓, 1,

Functional Outcomes ⓘ

cognitive↑, 1,
Total Targets: 3

Scientific Paper Hit Count for: SAM-e, S-adenosylmethionine

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells