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| Sesame (particularly sesame seeds and sesame oil) has been studied for its potential neuroprotective effects, including relevance to Alzheimer’s disease (AD) Sesame (seeds/oil) — AD relevance: Preclinical literature (sesamin/sesamolin/sesamol and sesame oil) supports neuroprotection via antioxidant + anti-inflammatory mechanisms, with reported effects on amyloid toxicity/aggregation in models. Human AD-specific clinical evidence is limited. Primary mechanisms (conceptual rank): Bioavailability / PK relevance: Effects are typically chronic (weeks) and metabolite/remodeling driven. Clinical evidence status: Predominantly preclinical for AD mechanisms; not established as disease-modifying in humans. -Sesame seeds are rich in sesamin, sesamol, and sesaminol, lignans with strong antioxidant properties.-Sesamol has been shown to inhibit pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, and suppress NF-κB signaling -may inhibit acetylcholinesterase (AChE) -Sesamol may help inhibit Aβ aggregation Mechanism Effect ↓ ROS (Oxidative stress) Protects neurons from oxidative damage ↓ NF-κB Reduces neuroinflammation ↓ AChE Increases acetylcholine levels ↓ Aβ aggregation Limits amyloid plaque formation ↑ BDNF Supports neurogenesis Nutritional Richness -Healthy fats: High in monounsaturated and polyunsaturated fats (especially omega-6) -Protein: A good plant-based protein source -Minerals: Rich in calcium, magnesium, iron, zinc, selenium, and copper -Vitamins: Contains B vitamins (especially B1, B3, B6), vitamin E -High in calories and fats—consume in moderation Sesame Seeds / Sesame Oil — AD / Neurodegeneration Pathway Map
TSF legend: P: 0–30 min; R: 30 min–3 hr; G: >3 hr |
| Source: HalifaxProj(inhibit) |
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| Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals. -Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis. -COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors. COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers. The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression: Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways. Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer. Drugs specifically targeting COX-2, such as celecoxib, have been developed. COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS. |
| 4190- | Sesame, | Sesame Seeds: A Nutrient-Rich Superfood |
| - | Review, | NA, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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