Safflower yellow / ChAT Cancer Research Results

SY, Safflower yellow: Click to Expand ⟱
Features:
Safflower yellow (SY), a natural pigment extracted from the petals of Carthamus tinctorius (safflower), has shown neuroprotective effects in several models of neurodegenerative diseases, including Alzheimer’s disease (AD).
-SY was found to improve learning and memory in AD animal model
-SY increases SOD and decreases MDA, a marker of lipid peroxidation
-SY downregulates pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α in brain tissues.
ChAT, Choline acetyltransferase: Click to Expand ⟱
Source:
Type:
Choline acetyltransferase (ChAT) is the enzyme responsible for synthesizing acetylcholine (ACh), a key neurotransmitter involved in memory, learning, and attention.
In AD, one of the hallmark neurochemical findings is a loss of cholinergic neurons, especially in the basal forebrain, leading to:
↓ ChAT activity
↓ Acetylcholine (ACh) levels
↓ Cognitive function (especially memory and attention)

Many AD drugs aim to increase ACh levels by:
-Inhibiting acetylcholinesterase (AChE) (which breaks down ACh), e.g., donepezil, rivastigmine.


Scientific Papers found: Click to Expand⟱
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, NA, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 1,   ChAT↑, 1,   TrkB↑, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: ChAT, Choline acetyltransferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:366  Target#:1346  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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