Safflower yellow / SOD Cancer Research Results

SY, Safflower yellow: Click to Expand ⟱
Features:
Safflower yellow (SY), a natural pigment extracted from the petals of Carthamus tinctorius (safflower), has shown neuroprotective effects in several models of neurodegenerative diseases, including Alzheimer’s disease (AD).
-SY was found to improve learning and memory in AD animal model
-SY increases SOD and decreases MDA, a marker of lipid peroxidation
-SY downregulates pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α in brain tissues.
SOD, superoxide dismutase: Click to Expand ⟱
Source:
Type:
SOD, or superoxide dismutase, is an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative stress. It catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide.
SOD Isoforms: There are three main isoforms of SOD:
SOD1 (cytosolic): Often found to be overexpressed in certain tumors, which may help cancer cells survive in oxidative environments.
SOD2 (mitochondrial): Plays a critical role in protecting mitochondria from oxidative damage. Its expression can be upregulated in some cancers, contributing to tumor growth and resistance to therapy.
SOD3 (extracellular): Its role in cancer is less well understood, but it may have implications in the tumor microenvironment and metastasis.
The expression levels of SOD can serve as a prognostic indicator in some cancers. For example, high levels of SOD expression have been associated with poor prognosis in certain types of tumors, potentially due to their role in promoting tumor cell survival and resistance to therapies.
Scientific Papers found: Click to Expand⟱
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, NA, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 1,   ChAT↑, 1,   TrkB↑, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: SOD, superoxide dismutase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:366  Target#:298  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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