Zerumbone / iNOS Cancer Research Results

ZER, Zerumbone: Click to Expand ⟱
Features:
Zerumbone is a sesquiterpene α,β-unsaturated carbonyl compound derived primarily from Zingiber zerumbet (shampoo ginger). It is one of the most intensively studied dietary terpenoids for anticancer activity, with a strong and internally consistent mechanism-of-action profile across multiple cancer types.
Zerumbone induces intrinsic (mitochondrial) apoptosis via:
-↑ ROS generation in cancer cells
-Loss of mitochondrial membrane potential
-↑ Bax / ↓ Bcl-2 and Bcl-xL
-Cytochrome c release
-Caspase-9 → caspase-3 activation

Zerumbone is a potent NF-κB inhibitor
Anti-angiogenic and anti-metastatic effects
-Observed actions include:
-↓ VEGF and HIF-1α
-↓ MMP-2 / MMP-9
-Suppression of EMT markers (N-cadherin, vimentin)
-Reduced migration and invasion

Zerumbone is a redox-bifunctional agent:
In cancer cells:
-↑ ROS beyond survival threshold
-Triggers mitochondrial collapse

In normal cells:
-Activates Nrf2
-Induces phase II detox enzymes (HO-1, NQO1, GST)

This differential redox response explains selective toxicity.
Bioavailability is limited


iNOS, Inducible nitric oxide synthase: Click to Expand ⟱
Source: HalifaxProj(block)
Type:
An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.
Scientific Papers found: Click to Expand⟱
4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, *COX2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:384  Target#:159  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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