Zerumbone / survivin Cancer Research Results

ZER, Zerumbone: Click to Expand ⟱
Features:
Zerumbone is a sesquiterpene α,β-unsaturated carbonyl compound derived primarily from Zingiber zerumbet (shampoo ginger). It is one of the most intensively studied dietary terpenoids for anticancer activity, with a strong and internally consistent mechanism-of-action profile across multiple cancer types.
Zerumbone induces intrinsic (mitochondrial) apoptosis via:
-↑ ROS generation in cancer cells
-Loss of mitochondrial membrane potential
-↑ Bax / ↓ Bcl-2 and Bcl-xL
-Cytochrome c release
-Caspase-9 → caspase-3 activation

Zerumbone is a potent NF-κB inhibitor
Anti-angiogenic and anti-metastatic effects
-Observed actions include:
-↓ VEGF and HIF-1α
-↓ MMP-2 / MMP-9
-Suppression of EMT markers (N-cadherin, vimentin)
-Reduced migration and invasion

Zerumbone is a redox-bifunctional agent:
In cancer cells:
-↑ ROS beyond survival threshold
-Triggers mitochondrial collapse

In normal cells:
-Activates Nrf2
-Induces phase II detox enzymes (HO-1, NQO1, GST)

This differential redox response explains selective toxicity.
Bioavailability is limited


survivin, BIRC5: Click to Expand ⟱
Source:
Type: antiapoptosis protein
Survivin, BIRC5 (Baculoviral IAP Repeat Containing 5) is a potent anti-apoptosis protein that is differentially expressed in cancer and therefore constitutes an important anti-cancer target [49]. Moreover, high expression of survivin plays important role in resistance to chemo- and radiotherapy and has been shown to be related to unfavorable outcome for medulloblastomas.
"Survivin" is a protein that plays a crucial role in regulating cell division and inhibiting apoptosis (programmed cell death). It is part of the inhibitor of apoptosis (IAP) family and is often overexpressed in various types of cancer.
Scientific Papers found: Click to Expand⟱
4888- ZER,  5-FU,    Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts
- in-vitro, CRC, CT26
TumVol↓, *tumCV↓, survivin↓, β-catenin/ZEB1↓, Vim↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

survivin↓, 1,  

Migration ⓘ

Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics ⓘ

tumCV↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: survivin, BIRC5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:384  Target#:299  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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