Zerumbone / TNF-α Cancer Research Results

ZER, Zerumbone: Click to Expand ⟱

Features:

Zerumbone is a sesquiterpene α,β-unsaturated carbonyl compound derived primarily from Zingiber zerumbet (shampoo ginger). It is one of the most intensively studied dietary terpenoids for anticancer activity, with a strong and internally consistent mechanism-of-action profile across multiple cancer types.
Zerumbone induces intrinsic (mitochondrial) apoptosis via:
-↑ ROS generation in cancer cells
-Loss of mitochondrial membrane potential
-↑ Bax / ↓ Bcl-2 and Bcl-xL
-Cytochrome c release
-Caspase-9 → caspase-3 activation

Zerumbone is a potent NF-κB inhibitor

Anti-angiogenic and anti-metastatic effects
-Observed actions include:
-↓ VEGF and HIF-1α
-↓ MMP-2 / MMP-9
-Suppression of EMT markers (N-cadherin, vimentin)
-Reduced migration and invasion

Zerumbone is a redox-bifunctional agent:
In cancer cells:
-↑ ROS beyond survival threshold
-Triggers mitochondrial collapse

In normal cells:
-Activates Nrf2
-Induces phase II detox enzymes (HO-1, NQO1, GST)

This differential redox response explains selective toxicity.
Bioavailability is limited

TNF-α, TNF-α: Click to Expand ⟱

Source: HalifaxProj (block)

Type:

Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation. TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development.
Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment.

Scientific Papers found: Click to Expand⟱

4889-

ZER,

Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha

in-vitro,

CRC,

HCT116

 5 μM and 10 μM

TumCP↓, TNF-α↓, *toxicity↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Migration ⓘ

TumCP↓, 1,

Immune & Inflammatory Signaling ⓘ

TNF-α↓, 1,
Total Targets: 2

Pathway results for Effect on Normal Cells:

Functional Outcomes ⓘ

toxicity↝, 1,
Total Targets: 1

Scientific Paper Hit Count for: TNF-α, TNF-α

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells