Sinapic acid / neuroP Cancer Research Results

SA, Sinapic acid: Click to Expand ⟱
Features:

Sinapic Acid - 3,5-Dimethoxy-4-Hydroxycinnamic Acid

Alternative Names: Sinapinic acid, 3,5-dimethoxy-4-hydroxycinnamic acid

Type: Hydroxycinnamic acid / phenolic acid / natural phytochemical

Sources: Widely distributed in fruits, vegetables, cereals, spices, and oilseed crops, with sinapic acid derivatives particularly abundant in plants of the Brassicaceae family.

Function: Sinapic acid is a bioactive phenolic acid with antioxidant, anti-inflammatory, anticancer, neuroprotective, and metal-chelating activities. Reported mechanisms include modulation of oxidative stress, inflammatory signaling, apoptosis, cell proliferation, mitochondrial function, and PI3K/AKT/GSK3β signaling.

Cancer: Preclinical studies demonstrate inhibition of cancer-cell proliferation, induction of apoptosis, suppression of inflammatory and oxidative signaling, and potential sensitization to chemotherapy and radiotherapy. Anticancer activity has been reported across several experimental tumor models.

Alzheimer's Disease: Preclinical studies demonstrate neuroprotective effects including reduced Aβ-associated neuronal injury, oxidative stress, neuroinflammation, and glial activation, with improvements in learning and memory. In APP/PS1 models, sinapic acid has also been reported to reduce Aβ pathology and modulate PI3K/AKT/GSK3β signaling.
neuroP, neuroprotective: Click to Expand ⟱
Source:
Type:
Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
7830- SA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *NeuroI↓, *iNOS↓, *3-NT↓, *Ach↑, *ChAT↑, *Dose↝, *neuroP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

3-NT↓, 1,   NeuroI↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChAT↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: neuroP, neuroprotective
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:454  Target#:1105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page