Extracorporeal Shock Wave Therapy / EPR Cancer Research Results

ESWT, Extracorporeal Shock Wave Therapy: Click to Expand ⟱
Features:

Extracorporeal Shock Wave Therapy - Underwater / Focused Shock Wave Treatment

Recommended Abbreviation: ESWT

Alternative Names: Extracorporeal shock waves, ESW, shock wave therapy, underwater shock waves, focused shock wave therapy

Type: Physical therapy / acoustic-mechanical intervention / experimental anticancer treatment

Function: Extracorporeal shock waves are high-pressure acoustic pulses transmitted through a material medium into biological tissue. Shock waves produce rapid mechanical stress, pressure gradients, cavitation-related effects, and transient increases in cell-membrane permeability. Depending on energy and treatment parameters, these effects can alter cellular signaling, drug uptake, vascular responses, apoptosis, and tissue remodeling.

Cancer: Preclinical studies demonstrate direct cytotoxic and pro-apoptotic effects in multiple cancer models and increased tumor-cell permeability to anticancer drugs and other therapeutic molecules. Shock waves can enhance the cytotoxic activity of agents including cisplatin, doxorubicin, bleomycin, and paclitaxel and have been investigated for drug delivery and sonodynamic approaches. Direct shock-wave treatment of malignant tumors remains experimental and is not an established standard cancer therapy.

Clinical Status: Established extracorporeal shock wave therapy is primarily used for musculoskeletal and rehabilitation indications. Active malignant tissue within the treatment field is generally considered a contraindication for routine clinical ESWT, despite experimental research investigating direct antitumor applications.
EPR, enhanced permeability and retention (EPR) effect: Click to Expand ⟱
Source:
Type:
Passive accumulation (in cells) is based on the unique architecture of the tumor tissue, where neo-angiogenesis leads to an atypical endothelial layer and to fenestrated vasculature, which together with the impaired lymphatic drainage guides the penetration and accumulation of nano-sized materials within the cancerous tissues.
Exploited for drug design in the nanomedicine field.
Scientific Papers found: Click to Expand⟱
7687- iod,  ESWT,    Shock Wave Application Increases the Antineoplastic Effect of Molecular Iodine Supplement in Breast Cancer Xenografts
- in-vivo, BC, MDA-MB-231
antiNeop↑, CSCsMark↓, CD44↓, SOX2↓, HIF-1↓, VEGF↓, Dose↝, Dose↝, EPR↝, PPARγ↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCsMark↓, 1,   SOX2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↝, 1,   HIF-1↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EPR, enhanced permeability and retention (EPR) effect
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:457  Target#:612  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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