Butein / GSR Cancer Research Results

BUT, Butein: Click to Expand ⟱
Features:

Butein - 2',3,4,4'-Tetrahydroxychalcone

Type: Chalcone / polyphenolic flavonoid-related compound

Function: Butein is a chalcone/polyphenol found in plants such as Rhus verniciflua, Dalbergia odorifera, and Butea monosperma. Butein is a naturally occurring chalcone with antioxidant, anti-inflammatory, and antiproliferative activity. It can modulate signaling pathways including STAT3, NF-κB, PI3K/AKT, MAPK, and redox-sensitive pathways and can influence apoptosis, cell-cycle progression, migration, invasion, and angiogenesis.

Cancer: Preclinical studies show broad anticancer activity, including inhibition of proliferation, migration, invasion, epithelial-mesenchymal transition, angiogenesis, and pro-survival signaling, together with induction of apoptosis and cell-cycle arrest in multiple cancer models.
GSR, Glutathione Reductase: Click to Expand ⟱
Source:
Type:
Glutathione reductase is an enzyme that plays a crucial role in maintaining the balance of glutathione, a powerful antioxidant found in cells. Glutathione is involved in various cellular processes, including detoxification, cell signaling, and protection against oxidative stress. Glutathione reductase helps maintain the levels of reduced glutathione (GSH) in cells. Cancer cells often have elevated levels of glutathione reductase, which allows them to maintain high levels of GSH and resist oxidative stress.
Glutathione reductase has been shown to promote cell proliferation and survival in cancer cells. Elevated levels of glutathione reductase have been found in various types of cancer, including breast, lung, and colon cancer.
Several studies have shown that inhibiting glutathione reductase can increase the sensitivity of cancer cells to chemotherapy and radiation therapy, and may also induce apoptosis in cancer cells.
Scientific Papers found: Click to Expand⟱
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   ROS↓, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bcl-2↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: GSR, Glutathione Reductase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:458  Target#:633  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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