Morin / compI Cancer Research Results

MOR, Morin: Click to Expand ⟱
Features:

Morin - 2',3,4',5,7-Pentahydroxyflavone

Recommended Abbreviation: MOR

Type: Flavonol / polyphenolic flavonoid

Sources: Morin occurs naturally in several plants and foods, including members of Morus, Maclura, Artocarpus, and Psidium species.

Function: Morin is a polyphenolic flavonol with antioxidant, anti-inflammatory, metabolic, neuroprotective, and antiproliferative activities. It modulates oxidative stress, mitochondrial function, inflammatory signaling, apoptosis, cell-cycle regulation, and signaling pathways including NF-κB, STAT3, PI3K/AKT, MAPK, and GSK-3β.

Cancer: Preclinical studies show broad anticancer activity. Morin can inhibit proliferation, migration, invasion, epithelial-mesenchymal transition, inflammatory signaling, and angiogenic pathways while promoting apoptosis and cell-cycle arrest. Reported molecular pathways include STAT3, NF-κB, PI3K/AKT, MAPK, Hippo, MMPs, and ROS-related signaling. Human anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence suggests neuroprotective activity. Morin can reduce amyloid-β-induced oxidative stress, mitochondrial dysfunction, calcium dysregulation, and neuronal injury and may inhibit GSK-3β-related signaling relevant to tau hyperphosphorylation and amyloid pathology. Evidence remains experimental, with no established clinical efficacy for Alzheimer's disease.
compI, mitochondrial complex-I: Click to Expand ⟱
Source:
Type:
Mitochondrial complex I (NADH:ubiquinone oxidoreductase) is the largest enzyme of the oxidative phosphorylation system. Its function is essential for bioenergetics and redox balance. Altered expression of its subunits can lead to changes in tumor metabolism, reactive oxygen species (ROS) generation, and apoptotic sensitivity—all of which may impact tumor growth and patient outcomes.

Commonly Reported Complex I Subunit:
-Increased expression of NDUFA4L2 has been associated with poor prognosis
-Reduced expression of core complex I subunits (such as NDUFS1 and NDUFS3) may correlate with a poorer overall survival in some cancers
-NDUFV1 have been linked to adverse clinical outcomes

-Dysregulation of complex I may alter ROS production. In some cancers, controlled ROS production can aid in signaling that promotes cell proliferation or survival, while excessive ROS can trigger cell death. Genes like NDUFA4L2 are also linked with hypoxia, a common feature in the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
7817- ISQ,  MOR,    Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis
- in-vitro, AD, NA
*neuroP?, *compI↑, *compIII↑, *compV↑, *p‑ERK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

compV↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

compI↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIII↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP?, 1,  
Total Targets: 5

Scientific Paper Hit Count for: compI, mitochondrial complex-I
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:460  Target#:1228  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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