Morin / Casp9 Cancer Research Results

MOR, Morin: Click to Expand ⟱

Features:

Morin - 2',3,4',5,7-Pentahydroxyflavone

Recommended Abbreviation: MOR

Type: Flavonol / polyphenolic flavonoid

Sources: Morin occurs naturally in several plants and foods, including members of Morus, Maclura, Artocarpus, and Psidium species.

Function: Morin is a polyphenolic flavonol with antioxidant, anti-inflammatory, metabolic, neuroprotective, and antiproliferative activities. It modulates oxidative stress, mitochondrial function, inflammatory signaling, apoptosis, cell-cycle regulation, and signaling pathways including NF-κB, STAT3, PI3K/AKT, MAPK, and GSK-3β.

Cancer: Preclinical studies show broad anticancer activity. Morin can inhibit proliferation, migration, invasion, epithelial-mesenchymal transition, inflammatory signaling, and angiogenic pathways while promoting apoptosis and cell-cycle arrest. Reported molecular pathways include STAT3, NF-κB, PI3K/AKT, MAPK, Hippo, MMPs, and ROS-related signaling. Human anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence suggests neuroprotective activity. Morin can reduce amyloid-β-induced oxidative stress, mitochondrial dysfunction, calcium dysregulation, and neuronal injury and may inhibit GSK-3β-related signaling relevant to tau hyperphosphorylation and amyloid pathology. Evidence remains experimental, with no established clinical efficacy for Alzheimer's disease.

Casp9, Caspase-9: Click to Expand ⟱

Source:

Type:

Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.

Scientific Papers found: Click to Expand⟱

7798-

ISQ,

MOR,

Several targets involved in Alzheimer's disease amyloidogenesis are affected by morin and isoquercitrin

in-vitro,

AD,

*ROS↓, *Casp3↓, *Casp8↓, *Casp9↓, *Aβ↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,

Cell Death(tgid=5) ⓘ

Casp3↓, 1, Casp8↓, 1, Casp9↓, 1,

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,
Total Targets: 5

Scientific Paper Hit Count for: Casp9, Caspase-9

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells