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| Mung Bean Sprouts - Vigna radiata Sprouts Alternative Names: Mung bean sprouts, green gram sprouts, Vigna radiata sprouts Type: flavonoid-rich functional food Source: Germinated seeds of Vigna radiata. Active Constituents: Mung bean sprouts contain flavonoids including vitexin and isovitexin, phenolic acids, GABA, proteins, peptides, vitamins, minerals, and other antioxidant phytochemicals. Sprouting substantially alters the phytochemical and nutritional profile compared with unsprouted mung beans. Function: Mung bean sprouts exhibit antioxidant, anti-inflammatory, metabolic, and cytoprotective effects. Sprouting can increase the availability of bioactive phenolic and flavonoid compounds and modify carbohydrate, protein, and antinutritional components. Reported biological effects include modulation of oxidative stress, inflammatory signaling, glucose and lipid metabolism, and cellular stress responses. Cancer: Preclinical evidence suggests antiproliferative and antioxidant effects from mung bean sprout extracts and constituent flavonoids, including vitexin and isovitexin. Potential mechanisms include modulation of oxidative stress, inflammatory signaling, apoptosis, and cell proliferation. Direct clinical anticancer evidence for mung bean sprouts is not established. Alzheimer's Disease: Evidence is limited and primarily indirect or preclinical. Antioxidant, anti-inflammatory, and metabolic effects of mung bean sprouts and their flavonoid constituents may be relevant to neuroprotection, but efficacy for Alzheimer's disease has not been established. -"Phenolic acids in mung bean can be divided into hydroxycinnamic acids (p-coumaric, ferulic, sinapic, and caffeic acid), hydroxybenzoic acids (gallic, syringic, protocatechuic,vanillic, and gentisic acid), and caffeoylquinic acid isomer (chlorogenic acid)"-"Flavonoids detected include flavones (vitexin, isovitexin, isovitexin-6″-O-α- L -glucoside, dulcinoside, and luteolin), flavonols (quercetin, myricetin, and kaempferol), and flavanols (catechin), and several mung bean flavonoids are also found in bound forms, such as quercetin, luteolin, and kaempferol." -"The content of each phenolic compound in mung bean is greatly affected by the cultivars, the place where they grow, as well as the extraction and analytical methods. Generally, vitexin (12−300 mg/100 g) and isovitexin (3−532 mg/100 g) are usually the most abundant phenolic compounds detected, and are regarded as the major bioactive compounds in mung bean." -"several polyphenols can only be detected in seed coat rather than cotyledon, including vitexin, isovitexin, vanillic acid, and catechin" |
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| (Also known as Hsp32 and HMOX1) HO-1 is the common abbreviation for the protein (heme oxygenase‑1) produced by the HMOX1 gene. HO-1 is an enzyme that plays a crucial role in various cellular processes, including the breakdown of heme, a toxic molecule. Research has shown that HO-1 is involved in the development and progression of cancer. -widely regarded as having antioxidant and cytoprotective effects -The overall activity of HO‑1 helps to reduce the pro‐oxidant load (by degrading free heme, a pro‑oxidant) and to generate molecules (like bilirubin) that can protect cells from oxidative damage Studies have found that HO-1 is overexpressed in various types of cancer, including lung, breast, colon, and prostate cancer. The overexpression of HO-1 in cancer cells can contribute to their survival and proliferation by: Reducing oxidative stress and inflammation Promoting angiogenesis (the formation of new blood vessels) Inhibiting apoptosis (programmed cell death) Enhancing cell migration and invasion When HO-1 is at a normal level, it mainly exerts an antioxidant effect, and when it is excessively elevated, it causes an accumulation of iron ions. A proper cellular level of HMOX1 plays an antioxidative function to protect cells from ROS toxicity. However, its overexpression has pro-oxidant effects to induce ferroptosis of cells, which is dependent on intracellular iron accumulation and increased ROS content upon excessive activation of HMOX1. -Curcumin Activates the Nrf2 pathway leading to HO‑1 induction; known for its anti‑inflammatory and antioxidant effects. -Resveratrol Induces HO‑1 via activation of SIRT1/Nrf2 signaling; exhibits antioxidant and cardioprotective properties. -Quercetin Activates Nrf2 and related antioxidant pathways; contributes to anti‑oxidative and anti‑inflammatory responses. -EGCG Promotes HO‑1 expression through activation of the Nrf2/ARE pathway; also exhibits anti‑inflammatory and anticancer properties. -Sulforaphane One of the most potent natural HO‑1 inducers; triggers Nrf2 nuclear translocation and upregulates a battery of phase II detoxifying enzymes. -Luteolin Induces HO‑1 via Nrf2 activation; may also exert anti‑inflammatory and neuroprotective effects in various cell models. -Apigenin Has been reported to induce HO‑1 expression partly via the MAPK and Nrf2 pathways; also known for anti‑inflammatory and anticancer activities. |
| 7834- | VA, | MBS, | Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review |
| - | Review, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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