Acer okamotoanum / Leptin Cancer Research Results

AO, Acer okamotoanum: Click to Expand ⟱
Features:

Acer okamotoanum - Acer okamotoanum Extract

Alternative Names: Acer okamotoanum, Ulleungdo maple

Type: Botanical extract / flavonoid-rich plant product

Source: Acer okamotoanum is a maple species native to Korea, particularly Ulleung Island. Experimental studies have used leaf extracts and solvent fractions, including flavonoid-rich ethyl acetate fractions.

Active Constituents: Reported constituents include isoquercitrin, quercitrin, afzelin, and other phenolic and flavonoid compounds.

Function: Acer okamotoanum extracts exhibit antioxidant, anti-inflammatory, cytoprotective, and neuroprotective activities. Experimental studies show reductions in reactive oxygen species, lipid peroxidation, inflammatory signaling, and apoptotic damage, together with preservation of neuronal viability and cellular stress resistance.

Alzheimer's Disease: Preclinical evidence suggests potential neuroprotective and cognition-preserving effects. Acer okamotoanum extract has improved learning and memory and reduced oxidative stress in experimental models involving amyloid-β and metabolic stress. Constituents including isoquercitrin, quercitrin, and afzelin may contribute to these effects through antioxidant, anti-inflammatory, and amyloid-related mechanisms. Clinical efficacy for Alzheimer's disease has not been established.
Leptin, Leptin: Click to Expand ⟱
Source:
Type:
Leptin is an adipokine elevated in obesity.
Many tumors overexpress the leptin receptor (Ob-R), creating autocrine/paracrine signaling loops.
Leptin acts as a pro-oncogenic signal integrator, linking:
-Adiposity
-Inflammation
-Growth factor signaling
-Metabolic reprogramming

1.Circulating leptin (systemic)
-Upregulated in obesity, which strongly correlates with higher cancer risk and worse outcomes in several tumor types.
-This creates a permissive, pro-tumor systemic environment.
2.Tumor leptin receptor (Ob-R) expression
-Frequently upregulated in tumors (and tumor stroma), even when circulating leptin is only modestly elevated.
-Leads to hypersensitivity to leptin.
3.Autocrine/paracrine leptin production
-Many tumors produce leptin locally, independent of adipose tissue.
-Establishes a self-reinforcing growth loop.
4.Downstream leptin signaling
-Consistently upregulated:
  -JAK2 → STAT3
  -PI3K → AKT → mTOR
  -APK/ERK
  -NF-κB
-These pathways drive proliferation, survival, angiogenesis, EMT, and therapy resistance.


Scientific Papers found: Click to Expand⟱
7839- AO,  ISQ,    The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
- in-vivo, AD, NA - in-vivo, Obesity, NA
*Dose↝, *Obesity↓, *Leptin↓, *adiP↑, *hepatoP↑, *PSEN1/PS1↓, *PSEN2/PS-2↓, *BACE/β-secretase↓, *eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   Obesity↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: Leptin, Leptin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:466  Target#:1421  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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