Isothiocyanates Cancer Research Results

ITCs, Isothiocyanates: Click to Expand ⟱
Features:

Isothiocyanates - ITCs

Abbreviation: ITCs

Type: Natural-product compound class / organosulfur phytochemicals

Source: Isothiocyanates are produced primarily from glucosinolates in cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, kale, Brussels sprouts, watercress, mustard, and related Brassicaceae plants. Tissue disruption allows myrosinase to hydrolyze glucosinolates and generate corresponding isothiocyanates.

Major Members:
Sulforaphane (SFN),
phenethyl isothiocyanate (PEITC),
benzyl isothiocyanate (BITC),
allyl isothiocyanate (AITC),
and other structurally related isothiocyanates.

Function: Isothiocyanates modulate cellular detoxification, oxidative-stress responses, inflammation, apoptosis, cell-cycle regulation, epigenetic signaling, and xenobiotic metabolism. Many ITCs activate NRF2-dependent cytoprotective pathways while also producing sufficient electrophilic and oxidative stress to inhibit cancer-cell growth.

Cancer: Isothiocyanates generally exhibit anticancer activity in preclinical models through apoptosis ↑, cell-cycle arrest ↑, detoxification enzyme activity ↑, NRF2 signaling modulation, inflammatory signaling ↓, proliferation ↓, angiogenesis ↓, migration/invasion ↓, and modulation of epigenetic enzymes including HDACs. Effects vary substantially among individual ITCs and cancer types.

Alzheimer's Disease: Selected isothiocyanates, particularly sulforaphane, show neuroprotective activity in experimental models through NRF2 activation, antioxidant defense ↑, neuroinflammation ↓, mitochondrial protection, and modulation of protein-clearance pathways. Evidence should generally be attributed to the specific isothiocyanate rather than assumed for the entire class.
Scientific Papers found: Click to Expand⟱
Showing Research Papers: 0 to 0 of 0

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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