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| Auraptene - 7-Geranyloxycoumarin Recommended Abbreviation: AUR Alternative Names: Aurapten, 7-geranyloxycoumarin Type: Natural product / prenylated coumarin / prenyloxycoumarin Source: Auraptene occurs naturally in several Rutaceae plants, including citrus fruits such as bitter orange, grapefruit, lemon, and related species, and has also been isolated from Aegle marmelos and Ferula species. Function: Auraptene exhibits anticancer, chemopreventive, anti-inflammatory, antioxidant, antimicrobial, metabolic, and neuroprotective activities. It modulates signaling pathways involved in proliferation, apoptosis, inflammation, xenobiotic metabolism, oxidative stress, and cellular differentiation. Cancer: Auraptene has demonstrated broad preclinical anticancer and chemopreventive activity. Reported effects include proliferation ↓, tumorigenesis ↓, migration/invasion ↓, cancer stem-like markers ↓, apoptosis ↑, caspase activation ↑, p53/p21 signaling ↑, and anti-apoptotic proteins such as MCL1 and BCL-xL ↓ in selected models. Auraptene can also increase sensitivity to anticancer drugs including cisplatin, paclitaxel, and 5-fluorouracil in experimental systems. Alzheimer's Disease: Auraptene has demonstrated experimental neuroprotective and anti-inflammatory activity relevant to neurodegenerative disease, but direct Alzheimer's disease evidence is less established than its cancer evidence. It is better classified as a potential neuroprotective compound rather than a well-established anti-Alzheimer agent. |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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