| Features: |
| Puerarin Recommended Abbreviation: PUE Alternative Names: Daidzein-8-C-glucoside Type: Natural product / isoflavone C-glycoside / phytoestrogen Source: Puerarin is a major bioactive isoflavone and one of the most abundant secondary metabolites in the root of Pueraria lobata (kudzu, Gegen). It also occurs in related Pueraria species. Function: Puerarin exhibits antioxidant, anti-inflammatory, neuroprotective, cardioprotective, metabolic, vasodilatory, and anticancer activities. It modulates multiple signaling networks involved in oxidative stress, apoptosis, inflammation, synaptic plasticity, mitochondrial function, and cellular metabolism. Cancer: Puerarin has demonstrated broad preclinical anticancer activity, including proliferation ↓, migration/invasion ↓, metastasis ↓, apoptosis ↑, and treatment sensitivity ↑. Reported mechanisms include modulation of NF-κB, ERK/MAPK, JAK2/STAT3, Wnt signaling, BAX/BCL-2 balance, caspases, MMPs, DUSP1, and drug-resistance pathways. Alzheimer's Disease: Puerarin has demonstrated neuroprotective activity in experimental Alzheimer's disease models. Reported effects include AChE activity ↓, COX-2 ↓, caspase-3 ↓, neuroinflammation ↓, oxidative stress ↓, neuronal apoptosis ↓, and antioxidant defenses ↑. Puerarin also supports synaptic plasticity through modulation of BDNF/TrkB, CREB, NMDA and AMPA receptor signaling, mitochondrial bioenergetics, long-term potentiation, and dendritic spine function. |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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