gefitinib, erlotinib / miR-200b Cancer Research Results

GB, gefitinib, erlotinib: Click to Expand ⟱
Features:
selectively targeting the mutant proteins in malignant cells.
epidermal growth factor receptor (EGFR) inhibitors (lung cancer)
miR-200b, miR-200b: Click to Expand ⟱
Source:
Type:
MicroRNA-200b (miR-200b) is encoded by the MIR200B gene, which is part of the microRNA-200 family located on chromosome 1 in humans. This microRNA plays a crucial role in the regulation of gene expression, particularly in processes related to epithelial-to-mesenchymal transition (EMT), cell proliferation, differentiation, and apoptosis.

miR-200b is generally considered antitumorigenic in many contexts. It plays a critical role in maintaining epithelial characteristics and inhibiting EMT, which is associated with reduced metastatic potential. By targeting genes involved in cell migration and invasion, miR-200b can suppress tumor progression.
Scientific Papers found: Click to Expand⟱
818- GAR,  GB,    Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs
- in-vitro, Lung, A549
miR-205↑, Let-7↑, Apoptosis↑, miR-200b↑, miR-218↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

miR-205↑, 1,   miR-218↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Let-7↑, 1,  

Migration ⓘ

miR-200b↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-200b, miR-200b
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:7  Target#:902  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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