| Features: Estrogen-like activity | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genistein is a naturally occurring isoflavone predominantly found in soy products. It binds estrogen receptors (with relative preference for ERβ over ERα), inhibits certain tyrosine kinases, and modulates PI3K/AKT, NF-κB, MAPK, and cell-cycle pathways in preclinical cancer models. It is also reported to influence angiogenesis and epigenetic regulation. Oral exposure produces conjugated metabolites (glucuronides/sulfates), and free genistein plasma levels are typically much lower than many in-vitro µM concentrations. -soy isoflavone Anticancer effects through several mechanisms: -Modulation of Hormone Activity: can bind to estrogen receptors(hormone-dependent cancers like breast and prostate cancer). -Inhibition of Cell Proliferation:- -inducing cell cycle arrest. -Induction of Apoptosis:- by influencing pro- and anti-apoptotic regulators. -Anti-inflammatory and Antioxidant Effects:-antioxidant properties help to neutralize ROS -Anti-angiogenic Activity:may also inhibit tumor angiogenesis Key Cellular Signaling Pathways Involved -Estrogen Receptor Signaling: interacting with estrogen receptors (ERα and ERβ) -PI3K/Akt/mTOR Pathway:inhibits this pro-survival pathway, leading to reduced cell growth -MAPK/ERK Pathway: can contribute to cell cycle arrest. -NF-κB Pathway:may downregulate NF-κB, supporting a reduction in tumor-promoting inflammation. -Wnt/β-catenin Pathway: involved in cell proliferation, differentiation, and oncogenic transformation. Dosages often ranging from approximately 40 mg to 100 mg per day for potential therapeutic effects. Genistein has limited bioavailability when ingested as part of the diet. Efforts to enhance its absorption include the use of specific formulations, such as those that combine genistein with other compounds or utilize novel delivery systems.
Time-Scale Flag (TSF): P / R / G
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| Source: HalifaxProj(inhibit) |
| Type: |
| A key component of the enzyme telomerase, which is responsible for maintaining the length of telomeres at the ends of chromosomes. In most somatic cells, telomerase activity is low or absent, leading to progressive telomere shortening with each cell division, which eventually triggers cellular senescence or apoptosis. many cancer cells exhibit reactivation of telomerase, primarily through the upregulation of hTERT. This reactivation allows cancer cells to maintain their telomere length, enabling them to divide indefinitely and contributing to the immortality characteristic of cancer cells. The expression of hTERT is often associated with various types of cancer, including melanoma, breast cancer, and lung cancer. | Cancer context | TERT biomarker | Clinical use | | -------------- | ----------------------------- | ---------------------------------------- | | Glioma | Promoter mutation | **WHO classification, prognosis** | | Thyroid cancer | Promoter mutation | **Aggressiveness, recurrence risk** | | Melanoma | Promoter mutation | Risk stratification | | Bladder cancer | Promoter mutation (urine DNA) | **Noninvasive detection & surveillance** | | HCC | Promoter mutation | Early event, prognosis | Why TERT Is Valuable Despite Limited “Actionability” -Telomere maintenance is mandatory for long-term tumor survival -TERT activation is often an early, irreversible event -Its presence signals a tumor that has escaped replicative limits -That makes TERT one of the best markers of “point-of-no-return” biology. |
| 1435- | GEN, | SFN, | The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF-7 |
| 1504- | GEN, | Epigenetic targets of bioactive dietary components for cancer prevention and therapy |
| - | Review, | NA, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:85 Target#:150 State#:% Dir#:%
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