Database Query Results : , , AntiAg

AntiAg, Antiplatelet aggregation: Click to Expand ⟱
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Antiplatelet aggregation refers to the process by which platelets clump together to form a blood clot.
The plethora of evidence indicates that among multiple hemostasis components, platelets play major roles in cancer progression by providing surface and granular contents for several interactions as well as behaving like immune cells.On the other hand, there are suggestions that antiplatelet treatment may promote solid tumor development in a phenomenon described as “cancers follow bleeding.” The controversies around antiplatelet agents justify insight into the subject to establish what, if any, role platelet-directed therapy has in the continuum of anticancer management.
The interplay between antiplatelet aggregation and cancer is an area of active research, with potential implications for therapeutic strategies. Antiplatelet agents, such as aspirin, are being investigated for their role in cancer prevention and treatment, particularly in reducing metastasis and improving patient outcomes.
Scientific Papers found: Click to Expand⟱
5345- ,    Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation
- in-vitro, Nor, NA
*AntiAg↑,
4574- AgNPs,    Advances in nano silver-based biomaterials and their biomedical applications
- Review, NA, NA
*Wound Healing↑, *AntiThr↑, *AntiAg↑, eff↑,
4581- AgNPs,    Antimicrobial, anticoagulant and antiplatelet activities of green synthesized silver nanoparticles using Selaginella (Sanjeevini) plant extract
*Bacteria↓, *AntiAg↑, *toxicity↓,
4580- AgNPs,    Biogenic Synthesis of Antibacterial, Hemocompatible, and Antiplatelets Lysozyme Functionalized Silver Nanoparticles through the One-Step Process for Therapeutic Applications
- in-vitro, NA, NA
*AntiAg↑,
4579- AgNPs,    Response of platelets to silver nanoparticles designed with different surface functionalization
*AntiAg↑, *AntiThr↑, *Dose↝,
4577- AgNPs,    Characterization of Antiplatelet Properties of Silver Nanoparticles
- vitro+vivo, Stroke, NA
*AntiAg↑, *Bacteria↓, *Dose↝, *Dose↝, *Dose↝, *toxicity↝,
4576- AgNPs,    Nanosilver, Next-Generation Antithrombotic Agent
- Study, NA, NA
*AntiAg↑, *Bacteria↓,
2559- AL,    Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time
- Human, Nor, NA
AntiAg↑, COX2↓, cardioP↑,
2560- AL,    Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease
- ex-vivo, Nor, NA
*AntiAg↑, BioAv↝, Dose↝,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2462- AL,    Comparison of antiplatelet activity of garlic tablets with cardio-protective dose of aspirin in healthy volunteers: a randomized clinical trial
- Trial, Nor, NA
AntiAg∅,
2463- AL,    Garlic as an antithrombotic and antiplatelet aggregation agent
- Review, Nor, NA
AntiAg↑, other↑,
2658- AL,    The Toxic Effect Ways of Allicin on Different Cell Lines
- Review, Var, NA
*antiOx↑, *AntiAg↑, *cardioP↑, Ca+2↑, ROS↑, Casp↑, p38↑, MAPK↑, hepatoP↑, chemoP↑,
5353- AL,    Aged Garlic Extract May Be Safe for Patients on Warfarin Therapy
- Human, Nor, NA
*AntiAg↑, *toxicity↓, *cardioP↑, *Dose↝,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, NA, NA
*COX1↓, *COX2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
5408- ASA,    An aspirin a day keeps cancer at bay
- Review, Var, NA
TumMeta↓, TXA2↓, *AntiAg↑, COX1↓,
5400- ASA,    Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention
- Review, Nor, NA
Risk↓, *Inflam↓, *COX1↓, *AntiAg↑, *Half-Life↓, *BioAv↑,
5401- ASA,    Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15R-prostaglandins that inhibit platelet aggregation
- Review, Nor, NA
*AntiAg↑, *COX1↓,
5409- ASA,    Role of aspirin in cancer prevention
- Review, Var, NA
Imm↑, *Inflam↓, *AntiAg↑, *GutMicro↑, eff↑, TumMeta↓, angioG↓, Risk↓, Risk↓,
5405- ASA,    Exploring Aspirin’s Potential in Cancer Prevention: A Comprehensive Review of the Current Evidence
- Review, Var, NA
Risk↓, COX1↓, PGE2↓, Inflam↓, *AntiAg↓, PI3K↓, Akt↓, Risk↓,
2461- ASA,    Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis
- Review, NA, NA
AntiAg↑, COX1↓, eff↑,
4988- ATV,  Dipy,    Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines
- in-vivo, Melanoma, NA
HMGCR↓, SREBP2↑, SREBP2↓, AntiAg↑,
4986- ATV,  Dipy,    The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer
- Review, Var, NA
HMG-CoA↓, AntiAg↑, eff↑, Apoptosis↑, selectivity↑, *toxicity↓, TumCG↓, PDE4↓, other↑,
5366- AV,    Aloe vera: A review of toxicity and adverse clinical effects
- Review, Var, NA
*Dose↝, *toxicity↝, tumCV↓, *AntiAg↑,
4340- BBR,    Agonist-dependent differential effects of berberine in human platelet aggregation
- Human, NA, NA
*AntiAg↑, *other?,
4342- CA,    Antiplatelet effects of caffeic acid due to Ca(2＋) mobilizationinhibition via cAMP-dependent inositol-1, 4, 5-trisphosphate receptor phosphorylation
- in-vitro, NA, NA
*AntiAg↑, *TXA2↓, *COX1↓,
3890- Cin,    The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases
- Review, NA, NA
*cardioP↑, *Inflam↓, *ROS↓, *lipid-P↓, *AntiAg↑, *angioG↑, *GutMicro↑, *ER Stress↓,
2466- CUR,    Regulatory Effects of Curcumin on Platelets: An Update and Future Directions
- Review, Nor, NA
*AntiAg↑, *antiOx↑, *Inflam↓, *12LOX↑, COX1↓, COX2↓, MMP9↓, NF-kB↓,
4337- CUR,    Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling
- in-vitro, NA, NA
*AntiAg↑, *TXA2↓,
4989- Dipy,    Dipyridamole
- Review, NA, NA
AntiAg↑,
4341- EA,    Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation
- in-vitro, NA, NA
*AntiAg↑, *AntiAg↑,
2562- EGCG,    Green Tea Epigallocatechin 3-Gallate Reduced Platelet Aggregation and Improved Anticoagulant Proteins in Patients with Transfusion-Dependent β-Thalassemia: A Randomized Placebo-Controlled Clinical Trial
- Trial, NA, NA
AntiAg↑, other↝,
2563- EGCG,    Cardioprotective effect of epigallocatechin gallate in myocardial ischemia/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies
- Review, NA, NA
cardioP↑, ROS↑, AntiAg↑, eff↑, COX1↓,
2468- EGCG,    Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists
- in-vitro, Nor, NA
*AntiAg↑, *Ca+2↓,
2561- EGCG,  ASA,    Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
- ex-vivo, Nor, NA
AntiAg↑, eff↑, Half-Life↝, other∅,
824- GAR,    Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis
- in-vitro, NA, NA
AntiAg↓,
3722- Gb,    Alzheimer's disease: Research summaries – Do Ginkgo products help?
- Review, AD, NA
*memory↑, *AntiAg↑,
2464- GI,    The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *LDL↓, *AntiAg↑, *AntiAg∅,
2465- GI,    Effect of daily ginger consumption on platelet aggregation
- Trial, Nor, NA
AntiAg↝, Dose∅,
4343- H2,    Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation
- vitro+vivo, NA, NA
*antiOx↑, *AntiAg↑, *NO↑, *ERK↑,
4344- H2,    Hydrogen May Inhibit Collagen-Induced Platelet Aggregation: An ex vivo and in vivo Study
- in-vivo, NA, NA - ex-vivo, NA, NA
*AntiAg↑,
4347- H2,    Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study
- ex-vivo, NA, NA
*AntiAg↑,
4346- H2,    Medical Application of Hydrogen in Hematological Diseases
- Review, NA, NA
*AntiAg↑, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓,
4345- H2,    The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease
- Human, NA, NA
*Inflam↓, *antiOx↑, *ROS↓, *NLRP3↑, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAg↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
4010- K+,    Potassium-sparing diuretics might reduce risk of Alzheimer's disease
- Review, AD, NA
*Risk↓, *ROS↓, *Inflam↓, *AntiAg↑,
4339- LT,    Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis
- in-vivo, NA, NA
*AntiAg↑, *ROS↓,
4338- LT,    Luteolin: a natural product with multiple mechanisms for atherosclerosis
- Review, NA, NA
*Inflam↓, *ROS↓, *PDGF↓, *lipid-P↓, *AMPK↑, *SIRT1↑, *AntiAg↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2↓, *RAGE↓,
3285- Lyco,    Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study
- in-vitro, Nor, NA
*AntiAg↑, *eff↑,
3286- Lyco,    Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation
- in-vitro, Nor, NA
*AntiAg↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, AntiCan↑, *COX2↓, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓, TumCP↓, *AntiAg↑, mTOR↓, STAT3↓, ERK↓, p‑Akt↓, Bcl-2↓, ROS↑, PSA↓,
2970- PL,    Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K/Akt/mTOR and p38 signaling pathways
- in-vitro, AML, NA
AntiAg↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, p38↑, Casp3↑,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
2565- RES,    https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2007.06788.x
- in-vitro, NA, NA - in-vivo, NA, NA
AntiAg↑, TXA2↑, PKCδ↑, Dose↝,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
2567- RES,    Neuroprotective Effects of Resveratrol in Ischemic Brain Injury
- Review, Stroke, NA
*eff↑, *neuroP↑, *antiOx↑, *Inflam↓, *cardioP↑, *AntiAg↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
2564- RES,    Effect of resveratrol on platelet aggregation by fibrinogen protection
- in-vitro, NA, NA
AntiAg↑, antiOx↓, COX2↓,
2467- RES,    Resveratrol inhibits Ca2+ signals and aggregation of platelets
- in-vitro, Nor, NA
*AntiAg↑, Ca+2↓,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
4575- RT,  AgNPs,    Rutin-Loaded Silver Nanoparticles With Antithrombotic Function
- in-vivo, NA, NA
*AntiThr↑, *AntiAg↑, *antiOx↑, *Inflam↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 74

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   CYP1A1↑, 1,   GPx↑, 1,   GSH↓, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 11,   ROS↝, 1,   mt-ROS↑, 1,   Trx↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   OCR↑, 1,   e-Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 5,   ECAR↓, 1,   FASN↓, 1,   GLO-I↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   SREBP2↓, 1,   SREBP2↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 9,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 2,   BAD↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 1,   Casp↑, 3,   Casp3↓, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp6↑, 1,   cl‑Casp7↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   cFLIP↓, 3,   CK2↓, 2,   Cyt‑c↑, 4,   Diablo↑, 1,   DR5↓, 1,   cl‑IAP2↑, 1,   iNOS↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 3,   Mcl-1↓, 3,   p27↑, 3,   p38↓, 1,   p38↑, 3,   survivin↓, 3,   Telomerase↓, 3,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   other↑, 3,   other↝, 2,   other∅, 1,   p‑pRB↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,   HSPs↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNMTs↓, 1,   P53↓, 1,   P53↑, 5,   cl‑PARP↑, 1,   PARP1↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 4,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 2,   P21↑, 5,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 3,   ERK↓, 2,   p‑ERK↓, 1,   FOXM1↓, 2,   FOXO3↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 5,   p‑mTOR↓, 2,   PI3K↓, 7,   PTEN↓, 1,   PTEN↑, 3,   RAS↓, 2,   STAT3↓, 5,   TumCG↓, 3,   Wnt↓, 2,  

Migration ⓘ

5LO↓, 1,   AntiAg↓, 2,   AntiAg↑, 16,   AntiAg↝, 1,   AntiAg∅, 1,   Ca+2↓, 1,   Ca+2↑, 3,   cal2↑, 1,   CLDN2↓, 1,   CXCL12↓, 1,   E-cadherin↑, 3,   FAK↓, 1,   ITGB4↓, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 1,   PKCδ↓, 1,   PKCδ↑, 1,   Rho↑, 1,   ROCK1↑, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 4,   TumMeta↓, 6,   Twist↓, 2,   uPA↓, 2,   VCAM-1↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   EGFR↓, 3,   HIF-1↑, 1,   Hif1a↓, 4,   NO↓, 2,   TXA2↓, 2,   TXA2↑, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 6,   COX2↓, 8,   CXCR4↓, 1,   IL10↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 2,   NF-kB↓, 6,   NF-kB↑, 1,   PD-L1↓, 1,   PGE2↓, 3,   PSA↓, 3,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 2,   BioEnh?, 1,   ChemoSen↑, 6,   Dose↑, 1,   Dose↝, 2,   Dose∅, 1,   eff↑, 16,   Half-Life↝, 2,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 2,   BMPs↑, 1,   EGFR↓, 3,   FOXM1↓, 2,   HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 1,   PD-L1↓, 1,   PSA↓, 3,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   cardioP↑, 2,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   PDE4↓, 1,   Risk↓, 6,  
Total Targets: 209

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 18,   Catalase↑, 4,   Fenton↓, 1,   GPx1↑, 1,   GSH↑, 2,   H2O2↓, 1,   HO-1↑, 2,   Keap1↑, 1,   lipid-P↓, 5,   mt-lipid-P↓, 1,   MDA↓, 3,   Mets↝, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 4,   ROS↓, 17,   ROS↑, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SIRT3↑, 2,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   Insulin↑, 1,   MMP↑, 1,   mtDam↓, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis ⓘ

12LOX↑, 1,   Acetyl-CoA↓, 1,   ALAT↓, 1,   AMPK↑, 3,   FAO↑, 1,   FASN↓, 1,   H2S↑, 1,   LDL↓, 3,   NADH:NAD↑, 1,   NADPH↓, 1,   PPARγ↑, 2,   SIRT1↑, 4,  

Cell Death ⓘ

Akt↓, 1,   Casp3↓, 1,   Cyt‑c∅, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

AntiThr↑, 3,   other?, 1,   other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 2,   HSP70/HSPA5↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   ERK↑, 1,   FOXO↑, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   mTOR↓, 1,   PTEN↓, 1,  

Migration ⓘ

AntiAg↓, 1,   AntiAg↑, 54,   AntiAg∅, 1,   Ca+2↓, 1,   Cartilage↑, 1,   MMP9↓, 1,   MMPs↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   RAGE↓, 1,   Rho↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   NO↓, 2,   NO↑, 1,   TXA2↓, 2,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 4,   COX2↓, 6,   IFN-γ↓, 1,   IL1β↓, 4,   IL6↓, 3,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 23,   NF-kB↓, 7,   p65↓, 1,   TLR4↓, 3,   TNF-α↓, 5,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

ADAM10↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 2,   Dose↝, 8,   eff↑, 9,   Half-Life↓, 2,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 2,   GutMicro↑, 2,   IL6↓, 3,   RAGE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   cardioP↑, 12,   chemoPv↑, 1,   cognitive↑, 2,   hepatoP↑, 3,   memory↑, 4,   motorD↑, 1,   neuroP↑, 8,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 5,   toxicity↝, 3,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 5,   Sepsis↓, 1,  
Total Targets: 126

Scientific Paper Hit Count for: AntiAg, Antiplatelet aggregation
9 Aspirin -acetylsalicylic acid
8 Resveratrol
7 Silver-NanoParticles
7 Allicin (mainly Garlic)
6 Hydrogen Gas
4 EGCG (Epigallocatechin Gallate)
3 Dipyridamole
3 Lycopene
3 Quercetin
2 Atorvastatin
2 Curcumin
2 Ginger/6-Shogaol/Gingerol
2 Luteolin
2 Magnolol
2 Piperlongumine
2 Rutin
1 Apigenin (mainly Parsley)
1 Aloe anthraquinones
1 Berberine
1 Caffeic acid
1 Cinnamon
1 Ellagic acid
1 Garcinol
1 Ginkgo biloba
1 Honokiol
1 Potassium
1 Naringin
1 Oleocanthal
1 Selenium NanoParticles
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:10  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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