Database Query Results : , , RARβ

RARβ, RARβ (NR1B2): Click to Expand ⟱
Source:
Type:
The retinoic acid receptors (RARs) are members of the nuclear receptor superfamily and function as ligand-activated transcription factors.
Three main isoforms have been characterized:
• RARα (NR1B1)
• RARβ (NR1B2)
• RARγ (NR1B3)
They bind retinoic acid (the active metabolite of vitamin A) and regulate gene expression programs involved in cell differentiation, proliferation, and apoptosis.

RARβ is frequently found to be downregulated or silenced (often by promoter hypermethylation) in several cancers, including lung, breast, and prostate cancers.
• Its loss is thought to contribute to tumor progression by diminishing the retinoid-induced differentiation and apoptosis signals.
Decreased RARβ expression is often associated with a poorer prognosis.
Scientific Papers found: Click to Expand⟱
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
1102- BBR,    Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells
- in-vitro, Melanoma, B16-BL6
TumCMig↓, TumCI↓, EMT↓, p‑PI3K↓, p‑Akt↓, RARα↓, RARβ↑, RARγ↑, E-cadherin↑, N-cadherin↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

RARα↓, 1,   RARβ↑, 2,   RARγ↑, 1,   SIRT1↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   hTERT/TERT↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   HATs↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC8↓, 1,   HMTs↑, 1,   p‑PI3K↓, 1,  

Migration ⓘ

CDH1↑, 1,   E-cadherin↑, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Drug Metabolism & Resistance ⓘ

TET2↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,   hTERT/TERT↓, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RARβ, RARβ (NR1B2)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1002  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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