Database Query Results : , , LRP6

LRP6, Low-density lipoprotein receptor–related protein 6: Click to Expand ⟱
Source:
Type:
LRP6 (Low-density lipoprotein receptor–related protein 6) is a single-pass transmembrane co-receptor that plays an essential role in the canonical Wnt/β-catenin signaling pathway. Wnt signaling is critically involved in embryonic development, cell proliferation, differentiation, and tissue homeostasis. Dysregulation of this pathway is a well-known contributor to oncogenesis.

LRP6 plays a significant role in the regulation of the Wnt/β-catenin signaling pathway—a key driver in many cancers. Its overexpression is commonly observed in various tumor types and often correlates with an aggressive clinical profile, including poor survival outcomes. These findings not only underscore the importance of LRP6 as a prognostic biomarker but also highlight its potential as a target for novel therapeutic interventions.
Scientific Papers found: Click to Expand⟱
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF-7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
4632- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, SUM159
CSCs↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Wnt↓, p‑LRP6↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, SMAD2↓, SMAD3↓, TGF-β↓,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
1268- NCL,  carbop,    Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer
- in-vitro, Ovarian, NA
Wnt/(β-catenin)↓, ALDH1A1↓, LRP6↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CSCs↓, 2,   EMT↓, 2,   LRP6↓, 4,   p‑LRP6↓, 2,   Wnt↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Slug↓, 3,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 3,   TGF-β↓, 2,   TumCI↓, 2,   TumCMig↓, 3,   Vim↓, 3,   Zeb1↓, 3,   ZO-1↑, 1,   β-catenin/ZEB1↓, 3,  

Functional Outcomes ⓘ

chemoP↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LRP6, Low-density lipoprotein receptor–related protein 6
2 HydroxyTyrosol
1 Chlorogenic acid
1 Niclosamide (Niclocide)
1 carboplatin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1005  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page