Database Query Results : , , MKI67

MKI67, MKI67 (coding for the protein Ki-67): Click to Expand ⟱

Source:

Type: marker

MKI67 is the gene that encodes the Ki-67 protein, a well-established marker of cellular proliferation. Ki-67 is expressed during all active phases of the cell cycle (G1, S, G2, and mitosis) but is absent in resting (G0) cells. Because of its tight correlation with cell proliferation, Ki-67 is widely used in clinical and research settings to assess the growth fraction of a given cell population, particularly in cancer.

Tumors with high proliferative activity almost invariably show elevated levels of Ki-67. This increased expression is reflective of rapid cell division and active tumor growth.
High Ki-67 levels are frequently associated with more aggressive tumor behavior, increased likelihood of recurrence, and poorer overall survival in many cancer types.

Scientific Papers found: Click to Expand⟱

1132-

RT,

Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

>100uM

rutin may act as a breast-cancer-promoting phytoestrogen.

in-vitro,

BC,

MCF-7

Vim↑, N-cadherin↑, E-cadherin↓, TumCP↑, TumCMig↑, tumCV↑, MKI67↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Transcription & Epigenetics ⓘ

tumCV↑, 1,

Migration ⓘ

E-cadherin↓, 1, N-cadherin↑, 1, TumCMig↑, 1, TumCP↑, 1, Vim↑, 1,

Functional Outcomes ⓘ

MKI67↑, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: MKI67, MKI67 (coding for the protein Ki-67)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells