Database Query Results : , , SMAD5

SMAD5, SMAD5: Click to Expand ⟱
Source:
Type:
SMAD5 is a receptor-regulated SMAD (R-SMAD) protein that primarily transduces signals from the bone morphogenetic protein (BMP) family of cytokines.
SMAD5, together with SMAD1 and SMAD8, is activated by BMP receptors. Once phosphorylated, it forms complexes with the common mediator SMAD4.

In some studies, altered or reduced SMAD5 expression has been linked with the loss of BMP-mediated tumor-suppressive functions. This could, for example, compromise normal differentiation signals and enable unchecked proliferation.
Conversely, in contexts where active BMP signaling may promote aspects of tumor progression (such as invasion or metastasis), altered activity or overexpression of SMAD5 may correlate with aggressive cancer phenotypes.
Scientific Papers found: Click to Expand⟱
3501- MF,    Unveiling the Power of Magnetic-Driven Regenerative Medicine: Bone Regeneration and Functional Reconstruction
- Review, NA, NA
*VEGF↑, *BMPs↓, *SMAD4↑, *SMAD5↑, *Ca+2↑,
1133- SM,    Salvianolic Acid A, a Component of Salvia miltiorrhiza, Attenuates Endothelial-Mesenchymal Transition of HPAECs Induced by Hypoxia
- in-vitro, Nor, HPAECs
*ROS↓, *p‑Smad1↑, *p‑SMAD5↑, *SMAD2↓, *SMAD3↓, *p‑ERK↓, *p‑Cofilin↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,  

Migration ⓘ

Ca+2↑, 1,   p‑Cofilin↓, 1,   p‑Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↑, 1,   SMAD5↑, 1,   p‑SMAD5↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Clinical Biomarkers ⓘ

BMPs↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: SMAD5, SMAD5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1012  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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