Database Query Results : , , ERK5

ERK5, extracellular signal-regulated kinase 5: Click to Expand ⟱
Source:
Type:
ERK5 (extracellular signal-regulated kinase 5, also known as MAPK7)
ERK5 is part of the MAP kinase family and plays roles in cell proliferation, differentiation, survival, and angiogenesis. Its activation can be triggered by growth factors and various stress signals.

Elevated ERK5 activity is generally associated with:
-Enhanced tumor cell proliferation
-Increased metastatic potential
-Shorter survival times and poor prognosis in various cancers (particularly breast, lung, and prostate cancers)
Scientific Papers found: Click to Expand⟱
1136- SFN,    Sulforaphane inhibits epithelial-mesenchymal transition by activating extracellular signal-regulated kinase 5 in lung cancer cells
- in-vitro, Lung, NA - in-vivo, NA, NA
TumCMig↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Snail↓, ERK5↑, EMT↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK5↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCMig↓, 1,   ZO-1↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ERK5, extracellular signal-regulated kinase 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1014  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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