Database Query Results : , , MKK4

MKK4, Mitogen-Activated Protein Kinase Kinase 4: Click to Expand ⟱
Source:
Type:
MKK4 (Mitogen-Activated Protein Kinase Kinase 4), also known as MAP2K4 or SEK1, is a dual-specificity kinase that plays a role in activating the stress-activated protein kinases (SAPKs) including the Jun N-terminal Kinases (JNKs) and p38 pathways. These signaling cascades are involved in cellular responses to stress, inflammation, and apoptosis.

In some contexts, MKK4 is considered a tumor suppressor since its activation may trigger apoptosis or cell-cycle arrest in response to oncogenic stress.
However, there are instances where increased MKK4 activity is associated with cancer progression, potentially through its roles in cell migration or by promoting a tumor-promoting inflammatory microenvironment.
Scientific Papers found: Click to Expand⟱
2911- LT,    Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes
- in-vitro, Nor, HaCaT
*MMP1↓, *COX2↓, *IL6↓, *AP-1↓, *NF-kB↓, *ROS↓, *p‑MKK4↑, *p‑JNK↓, *p‑p38↓,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MKK4↓, 1,   Raf↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bax:Bcl2↑, 1,   BMP2↓, 1,   p38↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   p‑ERK↓, 1,  

Migration ⓘ

F-actin↓, 1,   MMP2↓, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

p‑MKK4↑, 1,  

Cell Death ⓘ

Akt↑, 1,   p‑JNK↓, 1,   p‑p38↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Migration ⓘ

AP-1↓, 1,   MMP1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL6↓, 1,   NF-kB↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 12

Scientific Paper Hit Count for: MKK4, Mitogen-Activated Protein Kinase Kinase 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1017  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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