Database Query Results : , , cPLA2

cPLA2, cytosolic phospholipase A2: Click to Expand ⟱

Source:

Type:

cPLA2 is a key enzyme that hydrolyzes membrane phospholipids to release arachidonic acid, serving as the precursor for the synthesis of eicosanoids (prostaglandins, leukotrienes, etc.).
These lipid mediators can significantly influence inflammation, cell proliferation, survival, angiogenesis, and metastasis—all processes that are critical in cancer development and progression.

cPLA2 plays a multifaceted role in carcinogenesis through its involvement in the production of bioactive lipids that regulate inflammation, cell growth, and metastasis. Its expression is frequently elevated in several cancers—including breast, prostate, colorectal, lung, ovarian, and head and neck cancers—and is generally associated with a poorer prognosis.

Scientific Papers found: Click to Expand⟱

1162-

PI,

Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response

in-vitro,

NA,

Rabbit platelets and murine macrophage RAW264.7 cells were treated with piperine

*cPLA2↓, TXA2↓, COX2↓, PGE2↓, PGD2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Angiogenesis & Vasculature ⓘ

TXA2↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, PGD2↓, 1, PGE2↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

cPLA2↓, 1,
Total Targets: 1

Scientific Paper Hit Count for: cPLA2, cytosolic phospholipase A2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells