Database Query Results : , , NPC1L1

NPC1L1, Niemann–Pick C1-Like 1: Click to Expand ⟱
Source:
Type:
NPC1L1 (Niemann–Pick C1-Like 1) is best known as a key mediator of intestinal cholesterol absorption and a target for cholesterol-lowering drugs (e.g., ezetimibe). Increasing evidence suggests that NPC1L1 may also play a role in cancer biology.

Overall, NPC1L1 is emerging as a potential biomarker of altered lipid metabolism in cancer, and future studies may help clarify its utility as a prognostic indicator or therapeutic target.
Scientific Papers found: Click to Expand⟱
1229- OA,    Review of the Clinical Effect of Orlistat
- Review, NA, NA
NPC1L1↓, FASN↓, ER Stress↑, angioG↓, TumCG↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

FASN↓, 1,   NPC1L1↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NPC1L1, Niemann–Pick C1-Like 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1050  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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