Database Query Results : , , IRAK4

IRAK4, interleukin-1 receptor-associated kinase 4: Click to Expand ⟱
Source:
Type:
IRAK4 (interleukin-1 receptor-associated kinase 4) is a serine/threonine kinase that plays a crucial role in mediating signaling downstream of toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Given its involvement in innate immune signaling and the inflammatory response, aberrations in IRAK4 expression or activity can influence oncogenic processes.

In hematological malignancies, particularly lymphomas and certain leukemias, increased IRAK4 expression and activity have been observed and are linked to sustained inflammatory signaling, contributing to aggressive disease features and poorer outcomes.

• In solid tumors, while data remain more heterogeneous, elevated IRAK4 levels in some cancers correlate with increased inflammation, tumor progression, and resistance to therapy.
Scientific Papers found: Click to Expand⟱
1231- PBG,    Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   FASN↓, 1,   HK2↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   IRAK4↓, 1,   NF-kB↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IRAK4, interleukin-1 receptor-associated kinase 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1051  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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