Database Query Results : , , OATPs

OATPs, Organic Anion Transporting Polypeptides: Click to Expand ⟱
Source:
Type:
• OATP1B1 and OATP1B3 are mainly liver-specific transporters normally responsible for hepatic drug and solute uptake.
– Their downregulation in HCC is associated with a loss of normal liver function and may indicate poorer prognosis.

• OATP1B3 is also found to be aberrantly overexpressed in certain extrahepatic cancers, raising interest as a potential diagnostic or therapeutic marker.

• OATP2B1 is more broadly expressed and its dysregulation in cancers like colorectal and prostate cancer might impact tumor behavior and treatment response, although further studies are needed to validate its prognostic significance.
Scientific Papers found: Click to Expand⟱
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, NA, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
1316- SIL,  Chemo,    Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
- Analysis, Var, NA
TumCCA↑, p42↓, P450↓, OATPs↓, chemoP↑, ChemoSen↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

p42↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Migration ⓘ

MMPs↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

OATPs↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,   P450↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   lipid-P↓, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

OCT4↓, 1,  

Barriers & Transport ⓘ

OATPs↓, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↓, 1,   IL2↓, 1,   IL4↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

hepatoP↑, 2,  
Total Targets: 19

Scientific Paper Hit Count for: OATPs, Organic Anion Transporting Polypeptides
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1053  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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