Database Query Results : , , EstroRS/ERS

EstroRS/ERS, Estrogen receptor signaling: Click to Expand ⟱
Source: HalifaxProj(suppress)
Type:
Estrogen receptor (ER) signaling plays a crucial role in various physiological processes, including the regulation of the menstrual cycle, reproductive functions, and bone health.
Often refered to as ERS.
There are two main types of estrogen receptors:

ERα (Estrogen Receptor Alpha): Primarily found in breast tissue, it is the most studied receptor in relation to breast cancer.
ERβ (Estrogen Receptor Beta): Found in various tissues, including the ovaries, prostate, and brain, its role in cancer is less well understood.
Approximately 70% of breast cancers are ER-positive, meaning they grow in response to estrogen. ER signaling promotes cell proliferation and survival, contributing to tumor growth.
ERS is one of the highest-impact biomarkers in all of oncology.

Therapy Selection (Primary, Decisive Use)
-ER+ → endocrine therapy backbone (SERMs, SERDs, aromatase inhibitors) ± combinations (e.g., CDK4/6 inhibitors)
-ER− → endocrine therapy ineffective

This single result defines first-line treatment in breast cancer.


Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EstroRS/ERS, Estrogen receptor signaling
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:107  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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