Database Query Results : , , cMYB

cMYB, c-MYB: Click to Expand ⟱
Source:
Type: marker
c‑MYB is a transcription factor that plays critical roles in cell proliferation, differentiation, and apoptosis.
– c‑MYB is a transcription factor essential for normal hematopoiesis and the regulation of genes involved in cell cycle progression, differentiation, and survival.

– Aberrant or sustained expression of c‑MYB is found in several malignancies, particularly hematological cancers such as acute leukemias, as well as solid tumors including breast and colon cancers.
– Overexpression or mutation of c‑MYB can lead to enhanced cell proliferation and impaired differentiation, creating an environment conducive to malignant transformation and tumor maintenance.
– In several studies, high levels of c‑MYB correlate with more aggressive tumor behavior and poorer clinical outcomes, such as reduced overall survival and an increased likelihood of relapse.

c‑MYB plays a pivotal role in the regulation of cell proliferation, differentiation, and survival. Its dysregulation in cancer contributes to unchecked growth and resistance to cell death, correlating with aggressive disease and poorer clinical outcomes.
Scientific Papers found: Click to Expand⟱
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
1498- SFN,    Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells
- in-vitro, CRC, HCT116 - in-vitro, Nor, NCM460
selectivity↑, TumCCA↑, Apoptosis↑, *p‑ERK↑, cMYB↓, selectivity↑, selectivity↑,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS?, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

BCR-ABL↓, 1,   Mortalin↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp12?, 1,   Casp3↑, 1,   Casp9↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,   m-FAM72A↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cMYB↓, 3,   CSCs↓, 1,   EMT↓, 1,   ERK↓, 1,   ERK↑, 1,   HDAC↓, 1,   Wnt↓, 1,  

Migration ⓘ

annexin II↓, 1,   E-cadherin↑, 1,   MMP1↓, 1,   MMP2↓, 2,   MMP9↓, 1,   ROCK1↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 1,   Hif1a↓, 2,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↑, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   eff↓, 1,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,  
Total Targets: 63

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: cMYB, c-MYB
2 Sulforaphane (mainly Broccoli)
1 Ashwagandha(Withaferin A)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1077  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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