Database Query Results : , , Paraptosis

Paraptosis, Paraptosis: Click to Expand ⟱
Source:
Type: type of cell death
Paraptosis is a form of programmed cell death that differs morphologically from apoptosis.
– Key features include pronounced cytoplasmic vacuolation, mitochondrial and/or endoplasmic reticulum (ER) swelling, and the absence of classical apoptotic markers (such as caspase activation, DNA fragmentation, and membrane blebbing).
– It is considered a caspase-independent cell death mechanism.
Scientific Papers found: Click to Expand⟱
2635- Api,  CUR,    Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
- in-vitro, Cerv, HeLa
TumCD↑, eff↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,
1359- Ash,    Withaferin A Induces ROS-Mediated Paraptosis in Human Breast Cancer Cell-Lines MCF-7 and MDA-MB-231
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
MMP↓, Alix/AIP‑1↓, ROS↑, Paraptosis↑, ER Stress↝,
1142- Ash,    Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer
- Review, BC, MCF-7 - NA, BC, MDA-MB-231 - NA, Nor, HMEC
Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,
1596- Cu,  CDT,    Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
- Review, NA, NA
TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, NA, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
1971- GamB,    Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, MDA-MB-468 - in-vivo, NA, NA
Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 2,   H2O2↑, 1,   OXPHOS↓, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 3,   mtDam↑, 1,   XIAP↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 2,   Casp3↑, 1,   Cupro↑, 2,   Cyt‑c↑, 1,   DR5↑, 1,   p‑JNK↑, 1,   Paraptosis↑, 6,   Pyro↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 3,   ER Stress↝, 1,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,  

Migration ⓘ

Alix/AIP‑1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose↝, 1,   eff↓, 4,   eff↑, 15,   RadioS↑, 1,   selectivity↑, 4,  
Total Targets: 38

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS∅, 2,  

Functional Outcomes ⓘ

toxicity↝, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Paraptosis, Paraptosis
2 Ashwagandha(Withaferin A)
2 Copper and Cu NanoParticlex
1 Apigenin (mainly Parsley)
1 Curcumin
1 chemodynamic therapy
1 Gambogic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1078  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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