Database Query Results : , , HDAC8

HDAC8, Histone deacetylase 8: Click to Expand ⟱
Source:
Type:
Histone deacetylase 8 (HDAC8) is one of the class I histone deacetylases involved in the removal of acetyl groups from histone and non-histone proteins. This deacetylation alters chromatin structure and gene expression and has been associated with various cellular processes including proliferation, apoptosis, and differentiation. Aberrant expression or activity of HDAC8 has been reported in several types of cancer where it can influence tumor behavior and prognosis.

– Studies report increased HDAC8 levels in certain aggressive tumor subtypes.
– Overexpression is often correlated with higher tumor grade, increased cell proliferation, and poorer patient outcomes.

HDAC8 overexpression is frequently associated with a more aggressive disease course and poorer prognosis in several types of cancer, including breast cancer, neuroblastoma, AML, and colorectal cancer. Its role in deacetylation and chromatin remodeling makes it an attractive target for therapeutic intervention, and ongoing studies aim to clarify its full prognostic and predictive value in cancer management.
Scientific Papers found: Click to Expand⟱
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2798- CHr,    Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
HDAC↓, HDAC8↓, TumCG↓, Diff↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
1505- CUR,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
TumCCA↑, Apoptosis↑, DNMTs↓, HDAC↓, HATs↓, TumCP↓, p300↓, HDAC1↓, HDAC3↓, HDAC8↓, NF-kB↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1506- RES,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, BRCA1↑, HDAC↓, SIRT1↑, p300↓, survivin↓, HDAC1↓, HDAC3↓, HDAC8↓,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1437- SFN,    Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
- Review, NA, NA
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, eff↑, ac‑HSP90↑, DNMT1↓, DNMT3A↓, hTERT/TERT↓, NRF2↑, HO-1↑, NQO1↑, miR-155↓, miR-200c↑, SOX9↓, *toxicity↓,
3322- SIL,    Therapeutic intervention of silymarin on the migration of non-small cell lung cancer cells is associated with the axis of multiple molecular targets including class 1 HDACs, ZEB1 expression, and restoration of miR-203 and E-cadherin expression
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, HATs↑, Zeb1↓, E-cadherin↑, TumCMig↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

Fenton↑, 1,   GSH↓, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↑, 5,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 2,   mtDam↑, 2,   OCR↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 3,   Glycolysis↓, 1,   HK2↓, 2,   LDH↓, 3,   PFK↓, 1,   PKM2↓, 2,   RARβ↑, 1,   SIRT1↓, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis?, 1,   Apoptosis↑, 3,   Bak↑, 1,   BAX↓, 1,   BAX↑, 1,   Casp3↓, 1,   Casp3↑, 2,   Casp9↑, 2,   Cyt‑c↑, 1,   hTERT/TERT↓, 3,   iNOS↑, 1,   MAPK↑, 1,   p27↑, 1,   p38↑, 1,   survivin↓, 2,  

Kinase & Signal Transduction ⓘ

SOX9↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   HATs↓, 1,   HATs↑, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   ac‑HSP90↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   DNAdam↑, 1,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 3,   P53↑, 1,   cl‑PARP↑, 1,   TP53↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 3,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   HDAC↓, 6,   HDAC1↓, 6,   HDAC2↓, 2,   HDAC3↓, 5,   HDAC4↓, 1,   HDAC8↓, 11,   HMTs↑, 1,   mTOR↓, 1,   p300↓, 2,   PI3K↓, 1,   PI3K↑, 1,   SCF↓, 1,   STAT3↓, 2,   STAT3↑, 1,   TumCG↓, 1,   Wnt↓, 2,  

Migration ⓘ

CDH1↑, 1,   E-cadherin↑, 1,   FAK↓, 1,   miR-155↓, 1,   miR-200c↑, 1,   MMP2↓, 1,   MMP9↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↑, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   eNOS↑, 1,   Hif1a↓, 1,   LOX1↓, 1,   NO↑, 1,   VEGF↓, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL10↓, 2,   IL4↓, 1,   Inflam↓, 2,   NF-kB↓, 4,   p65↓, 1,   PD-L1↓, 1,   TLR4↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 2,   Dose∅, 2,   eff↑, 8,   RadioS↑, 1,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

BRCA1↑, 1,   EZH2↓, 1,   hTERT/TERT↓, 3,   LDH↓, 3,   PD-L1↓, 1,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   OS↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 125

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSH↑, 1,   GSTs↑, 1,   NRF2↑, 1,   ROS↓, 2,  

Core Metabolism/Glycolysis ⓘ

NADPH↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 2,   TLR2↓, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   toxicity↓, 3,  
Total Targets: 11

Scientific Paper Hit Count for: HDAC8, Histone deacetylase 8
3 Chrysin
2 Sulforaphane (mainly Broccoli)
1 alpha Linolenic acid
1 Baicalein
1 Baicalin
1 Curcumin
1 Propolis -bee glue
1 Resveratrol
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1097  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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