Database Query Results : , , TFEB

TFEB, Transcription Factor EB: Click to Expand ⟱
Source:
Type:
TFEB is a member of the MiT/TFE (microphthalmia/transcription factor E) family and plays a crucial role in controlling the transcription of genes related to lysosome function and autophagy.
• Its subcellular localization (cytosolic versus nuclear) is tightly regulated, with nuclear translocation being associated with transcriptional activation of target genes.

TFEB is emerging as an important regulator in cancer biology, and its role as a prognostic marker is under active research. Its expression and activation state may offer insights into tumor behavior, especially regarding autophagy and metabolic adaptation.

Overexpressed in RCC, Pca,
Scientific Papers found: Click to Expand⟱
1455- SFN,    Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress
- in-vitro, Cerv, HeLa - in-vitro, Nor, 1321N1
*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TFEB↑, 1,   TumAuto↑, 1,  

Migration ⓘ

LAMP1?, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: TFEB, Transcription Factor EB
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1102  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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