Database Query Results : , , NKG2D

NKG2D, natural killer group 2, member D (NKG2D) ligands: Click to Expand ⟱
Source:
Type:
“NKG2D” itself is a receptor on immune cells, and most research focuses on its ligands—such as MICA, MICB, and the UL16-binding proteins (ULBPs)—that are expressed by tumor cells or within the tumor microenvironment.
MICA and MICB
• Expression:
– Frequently overexpressed on the surface of transformed cells in cancers such as colorectal, ovarian, breast, and pancreatic cancers.
• Prognosis:
– In some studies, high levels of MICA/B on tumor cells have been correlated with enhanced NK cell-mediated lysis and better prognosis.

2. ULBPs (ULBP1, ULBP2, ULBP3, etc.)
-Overexpression of certain ULBP family members has been associated with increased tumor recognition by NK and CD8⁺ T cells, potentially correlating with improved survival in some studies (e.g., ovarian cancer).
– In contrast, increased soluble ULBP levels have been linked to immune evasion and worse outcomes in other contexts.
Scientific Papers found: Click to Expand⟱
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
1470- SFN,  Rad,    Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, Lung, A549 - in-vitro, lymphoma, U937
eff↓, ROS↑, NKG2D↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   TAC?, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   DR4↑, 1,   DR5↑, 1,   p27↑, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   NOTCH⇅, 1,   NOTCH2↓, 1,   PTCH1↓, 1,   Smo↓, 1,   STAT3↓, 1,   STAT5↓, 1,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Functional Outcomes ⓘ

NKG2D↑, 2,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NKG2D, natural killer group 2, member D (NKG2D) ligands
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1104  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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