Database Query Results : , , CardioT

CardioT, Cardiotoxicity: Click to Expand ⟱
Source:
Type:
Cardiotoxicity in the context of cancer generally refers to the potential harmful effects that cancer therapies can have on the heart. This is an important consideration because many effective cancer treatments can also damage cardiac tissue, leading to short-term or long-term cardiovascular complications.

Mechanisms of Cardiotoxicity in Cancer Therapy
-Chemotherapy Agents:
     Anthracyclines (e.g., doxorubicin, epirubicin):
     Alkylating Agents (e.g., cyclophosphamide):
     Antimetabolites (e.g., 5-fluorouracil, capecitabine):
-Targeted Therapies:
    HER2 inhibitors (e.g., trastuzumab):
    Tyrosine Kinase Inhibitors (e.g., sunitinib, imatinib):
-Radiation Therapy:
    Thoracic irradiation:

Natural Products that may reduce Cardiotoxicity:
-Resveratrol
-Curcumin
-EGCG
-Quercetin
-Garlic Extract (Allicin)
-Omega-3 Fatty Acids: Fish oil (EPA and DHA), flaxseeds, chia seeds, walnuts.


Natural products like resveratrol, curcumin, EGCG, quercetin, garlic extract, and omega-3 fatty acids show potential in reducing cardiotoxicity by targeting oxidative stress, inflammation, and apoptotic pathways.
Scientific Papers found: Click to Expand⟱
1780- MEL,    Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing
- Review, Var, NA
*antiOx↑, *toxicity↓, ChemoSen↑, *eff↑, *mitResp↑, *ATP↑, *ROS↓, *CardioT↓, *GSH↑, *NOS2↓, *lipid-P↓, eff↑, *HO-1↑, *NRF2↑, *NF-kB↑, TumCP↓, eff↑, neuroP↑,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, eff↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1494- SFN,  doxoR,    Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- in-vivo, BC, NA - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
CardioT↓, *GSH↑, *ROS↓, *NRF2↑, NRF2∅, HDAC↓, DNMTs↓, Casp3↑, ER-α36↓, Remission↑, eff↑, ROS↑, selectivity?,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1495- SFN,  doxoR,    Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation
- in-vivo, Nor, NA
*CardioT↓, *NRF2↑, *eff↓, *ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Fenton↑, 1,   NRF2↑, 1,   NRF2∅, 1,   ROS↓, 1,   ROS↑, 3,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Apoptosis↑, 3,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp3↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

miR-30a-5p↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNMTs↓, 1,   GADD45A↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   p‑RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   FOXO4↑, 1,   Gli1↓, 1,   HDAC↓, 3,   HDAC2↓, 1,   HH↓, 2,   p‑PI3K↑, 1,   TumCG↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   ER-α36↓, 1,   MARK4↓, 1,   miR-155↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   chemoR↓, 1,   ChemoSen↑, 4,   eff↓, 1,   eff↑, 8,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 3,   selectivity?, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   CardioT↓, 3,   ChemoSideEff↓, 1,   neuroP↑, 3,   Remission↑, 1,   RenoP↑, 1,  
Total Targets: 62

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 3,   H2O2↑, 1,   HO-1↑, 2,   Iron↓, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 4,   ROS↓, 6,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   mitResp↑, 1,  

Cell Death ⓘ

JNK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv?, 1,   BioAv↝, 1,   eff↓, 1,   eff↑, 2,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

NOS2↓, 1,  

Functional Outcomes ⓘ

CardioT↓, 4,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 27

Scientific Paper Hit Count for: CardioT, Cardiotoxicity
3 Rosmarinic acid
3 Sulforaphane (mainly Broccoli)
2 doxorubicin
1 Melatonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1108  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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