Database Query Results : , , Dose

Dose, Dosage: Click to Expand ⟱
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Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
Scientific Papers found: Click to Expand⟱
257- AL,  Cisplatin,    Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors
- in-vitro, NSCLC, A549
ROS↑, HIF-1↓, E-cadherin↑, N-cadherin↓, antiOx↓, Dose↝,
1916- AL,    Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods
- Review, Nor, NA
*BioAv↝, *eff↓, *BioAv↝, *BioAv↝, *eff↑, *Half-Life∅, *eff↑, *eff↑, *Dose∅, *eff↑,
2560- AL,    Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease
- ex-vivo, Nor, NA
*AntiAg↑, BioAv↝, Dose↝,
2666- AL,    Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
- Review, Var, NA
Inflam↓, AntiCan↑, ROS↑, MAPK↑, JNK↑, TumAuto↑, other↑, Dose↝, MALAT1↓, Wnt↓, β-catenin/ZEB1↓,
304- ALA,    alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation
- in-vitro, Colon, HT-29
mt-ROS↑, Apoptosis↑, Casp3↑, DNAdam↑, Bcl-xL↓, Dose↝,
281- ALA,    Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
- in-vitro, Lung, H460
mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,
267- ALA,    α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
Apoptosis↑, ROS↑, PDK1↓, NRF2↓, PDK1↓, Bcl-2↓, Casp9↑, Dose∅,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *eff↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
3974- ALC,    Carnitine
- Review, AD, NA
*Dose↝, *cognitive↑,
4765- antiOx,  Chemo,    Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity – Exploring the armoury of obscurity
- Review, Var, NA
chemoP↑, ChemoSen↑, OS↑, Dose↑, Risk↓, eff↓,
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, eff↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
1541- Api,  EGCG,    Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence
- Human, NA, NA
OS↑, Remission↓, Dose∅,
1543- Api,    Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
- Review, NA, NA
TNF-α↓, IL1β↓, IL6↓, IL10↓, COX2↓, iNOS↓, Inflam↓, Dose∅, Dose∅,
1544- Api,    The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68
- in-vitro, Nor, WRL68
*SREBF2↓, *HMGCR↓, *Dose∅, *BioAv?,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
1553- Api,    Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
- Review, NA, NA
Dose∅, TumVol↓, Dose∅, COX2↓, Hif1a↓, TumCCA↑, P53↑, P21↑, Casp3↑, DNAdam↑, TumAuto↝,
1555- Api,    USDA Database for the Flavonoid Content of Selected Foods
- Analysis, NA, NA
Dose?,
1556- Api,    Dissolution and antioxidant potential of apigenin self nanoemulsifying drug delivery system (SNEDDS) for oral delivery
- Analysis, NA, NA
*BioAv↑, *Dose∅,
1559- Api,    Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment
- in-vitro, Lung, A549 - in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Dose↓, selectivity↑,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
2635- Api,  CUR,    Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
- in-vitro, Cerv, HeLa
TumCD↑, eff↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,
3887- Api,    The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *Aβ↓, *memory↑, *AChE↓, *Ach↑, *Dose↑, *BDNF↑, *TrkB↑, *p‑CREB↑, *BBB↑, *Ca+2?,
3819- Aroma,    Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
- Human, AD, NA - in-vitro, AD, NA
*cognitive↑, *Dose↝, *Aβ↓, *tau↓, *BDNF↑, *motorD↑,
2578- ART/DHA,  RES,    Synergic effects of artemisinin and resveratrol in cancer cells
- in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa
Dose↝, TumCMig↓, Apoptosis↑, necrosis↑, ROS↑, eff↑,
2569- ART/DHA,    A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction
- Human, Nor, NA
*Half-Life↝, BioAv↝, *Half-Life↓, BioAv↑, *Dose↝,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP↑, DR5↑, Dose↝, BG↓, DNMTs↓,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
4819- ASTX,    Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway
- in-vitro, BC, MCF-7
antiOx↑, AntiTum↑, TumCD↑, P53↑, P21↑, Apoptosis↑, Dose↝, Casp3↑,
4818- ASTX,  MEL,    Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,
4817- ASTX,    Low Dose Astaxanthin Treatments Trigger the Hormesis of Human Astroglioma Cells by Up-Regulating the Cyclin-Dependent Kinase and Down-Regulated the Tumor Suppressor Protein P53
- in-vitro, GBM, U251
Dose⇅, ROS∅, SOD↑, CDK1↑, P53↓, TumCP⇅, ROS↑,
4815- ASTX,    The Promising Effects of Astaxanthin on Lung Diseases
- Review, Var, NA
Dose↑, *BioAv↝, *BioAv↝, *antiOx↑, *NRF2↑, *ERK↓,
1519- Ba,    Baicalein inhibits KB oral cancer cells by inducing apoptosis via modulation of ROS
- in-vitro, Oral, KB
Apoptosis↑, Dose∅, ROS↑,
1520- Ba,    Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, TOV-21G
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, Chk2↑, Dose∅, p‑γH2AX↑, CDC25↓, CHK1↓, cycD1/CCND1↓, eff↓, 12LOX↓,
4304- Ba,    Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
- in-vitro, AD, NA
*tau↓, *Dose↝, *BioAv↓,
2597- Ba,    Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer
- Review, PC, NA
chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2612- Ba,  MF,    The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
- in-vitro, Melanoma, NA
SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,
2481- Ba,  Rad,    Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, KYSE150
12LOX↓, RadioS↑, Dose↝, RANTES↓, MCP1↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
2692- BBR,    Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, SaOS2 - in-vivo, NA, NA
Casp1↓, IL1β↓, TumCG↓, Dose↝, Apoptosis↑, Inflam↓,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
2721- BetA,    Proteomic Investigation into Betulinic Acid-Induced Apoptosis of Human Cervical Cancer HeLa Cells
- in-vitro, Cerv, HeLa
ROS↑, Dose↝, Bcl-2↓, BAX↑, ER Stress↑,
2734- BetA,    Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,
1566- betaCar,  Lyco,    Antioxidant and pro-oxidant effects of lycopene in comparison with beta-carotene on oxidant-induced damage in Hs68 cells
- in-vitro, Nor, HS68
*ROS↑, *ROS⇅, *Dose?,
2502- Bical,    Complete Response of Metastatic Androgen Receptor–Positive Breast Cancer to Bicalutamide: Case Report and Review of the Literature
- Case Report, BC, NA
Dose↝, Remission↑,
4622- Bor,    Boron Level in the Prostate of the Normal Human: A Systematic Review
- Review, BPH, NA
Dose↝,
4621- Bor,    Boron
- Review, BPH, NA
*other↝, Risk↑, *Dose↑,
4620- Bor,  BTZ,    Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
- Review, Var, NA - Review, Arthritis, NA - Review, Pca, NA
Risk↓, *memory↑, *Dose↑, Risk↓, other↝, *testos↑, other↝, Risk↓, TumCP↓, Apoptosis↑, eff↑,
4619- Bor,    Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article
- Review, Var, NA
Dose↝, Risk↓, *antiOx↓, *Inflam↓, ChemoSen↑, AntiCan↑, *PCNA↓, *ROS↓, other↝,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
4270- Bos,    Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *Aβ↓, *TNF-α↓, *IL1β↓, *lipid-P↓, *TAC↑, *BDNF↑, *β-catenin/ZEB1↑, *Dose↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
1650- CA,    Adjuvant Properties of Caffeic Acid in Cancer Treatment
- Review, Var, NA
ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2↓, ROS↑,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,
1517- CAP,    Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
- in-vitro, Bladder, TSGH8301 - in-vitro, CRC, T24
ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1/CCND1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,
1518- CAP,    Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo
- in-vitro, CRC, HCT116
ENOX2↑, TumCP↑, TumCMig↑, Dose?, eff↑,
3701- Chol,    Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation
- in-vivo, AD, NA
*Ach↑, *Aβ↓, *memory↑, *APP↓, *eff↑, *neuroP↑, *Dose↑,
2806- CHr,  Se,    Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy
- in-vitro, Var, NA
eff↑, selectivity↑, Dose↝, TrxR↓, GSH↓, MMP↓, ROS↑, H2O2↑,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, eff↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, eff↑, eff↑, eff↑, eff↑,
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,
1586- Citrate,    Extracellular Citrate Is a Trojan Horse for Cancer Cells
- in-vitro, Liver, HepG2
Dose?, ac‑H4↓, lipidDe↓, ACLY↓, selectivity↑, *ACLY∅, Glycolysis↓, NADH↓, OAA↑, other↑,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
1581- Citrate,    Hypothesis proved. . .citric acid (citrate) does improve cancer:A case of a patient suffering from medullary thyroid cancer
- Case Report, Thyroid, NA
OS↑, Weight↑, Dose∅, eff↑,
1582- Citrate,    Clinical report: A patient with primary peritoneal mesothelioma that has improved after taking citric acid orally
- Case Report, PerC, NA
Dose∅, Weight↑, OS↑,
1583- Citrate,    Extracellular citrate and metabolic adaptations of cancer cells
- Review, NA, NA
Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, eff↑, Apoptosis↑, TumCG↓, PFK1↓,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
4763- CoQ10,  Chemo,  doxoR,    Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
ChemoSen∅, antiNeop∅, *cardioP↑, Dose↝, selectivity↑, TumCG∅, TumCG∅, Apoptosis∅,
3630- Croc,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP↓, *Dose↝,
1598- Cu,    Targeting copper in cancer therapy: 'Copper That Cancer'
- Review, NA, NA
eff↓, eff↑, Dose∅, eff↑, angioG↑, ROS↑,
1569- Cu,    Copper Nanoparticles as Therapeutic Anticancer Agents
- Review, NA, NA
Dose∅, Dose∅, ROS↑,
1639- Cu,  HCAs,    Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
angioG↓, tumCV↓, Dose↓, ROS↑,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
eff↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
1616- CUR,  EA,    Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid
- in-vitro, Nor, NA
*MAOA↓, *Dose∅, Dose?,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
*OS↑, QoL↑, Dose↑, Dose↑, IL6↓, STAT3↓, NF-kB↓, COX2↓,
1977- CUR,    Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
- in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
TrxR↓, Dose↝, eff↑,
1980- CUR,  Rad,    Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
selectivity↑, RadioS↑, TrxR↓, ROS↑, ERK↑, Dose∅, cl‑PARP↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
3590- CUR,    The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?
- Review, Var, NA - Review, AD, NA
*BioAv↓, *BioAv↑, Dose↑, *Dose↝, *BBB↑, *cognitive↑, *BioAv↑,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
2816- CUR,    NEUROPROTECTIVE EFFECTS OF CURCUMIN
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *AP-1↓, *NF-kB↓, *HATs↓, *HDAC↑, Dose↑, *ROS↓, *cognitive↑, *Aβ↓,
2808- CUR,    Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- in-vitro, Liver, HUH7
Ferritin↓, IronCh↑, TumAuto↑, Apoptosis↑, eff↝, Dose↝,
1910- CUSP9,    A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
- Analysis, GBM, NA
Dose↝, QoL↑, Dose↝,
1879- DCA,    Long-term stabilization of metastatic melanoma with sodium dichloroacetate
- Case Report, Melanoma, NA
OS↑, toxicity↓, Dose∅, Dose∅, Dose∅, QoL∅,
1877- DCA,    Non-Hodgkin′s Lymphoma Reversal with Dichloroacetate
- Case Report, lymphoma, NA
Remission↑, p‑PDKs↓, Glycolysis↓, i-Ca+2↓, toxicity↓, Dose∅,
1873- DCA,    Dual-targeting of aberrant glucose metabolism in glioblastoma
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
PDKs↓, eff↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, eff↑, Dose∅, toxicity∅,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1868- DCA,  MET,    Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
- Case Report, NA, NA
eff↑, toxicity∅, MMP↓, Apoptosis↑, selectivity↑, pH↝, Dose↝, Dose↝, eff↑,
2152- dietFMD,    Prolonged Nightly Fasting and Breast Cancer Prognosis
- Analysis, BC, NA
eff↑, Dose↓, Risk↓,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, eff↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,
2165- dietP,  SFN,    Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study
- Trial, PC, NA
Dose↝, OS↑, eff↝,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1617- EA,  CUR,    The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
- in-vitro, Nor, NA
Dose∅, GSTs↓,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
2501- EGCG,    A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea
- Case Report, AML, NA
OS↑, Remission↑, eff↑, Dose↝,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3245- EGCG,    (−)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway
- in-vitro, Nor, PC12
*neuroP↑, *Shh↑, *Gli1↑, *n-MYC↑, *Dose↝,
4290- EGCG,    EGCG impedes human Tau aggregation and interacts with Tau
- in-vitro, AD, NA
*tau↓, *Dose↝, *neuroP↑, *antiOx↑,
1514- EGCG,    Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture
- in-vitro, Cerv, HeLa - in-vitro, Nor, MCF10
selectivity↑, *toxicity∅, TumCG↓, NADHdeh?, eff↑, ENOX2↓, Dose?,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
1975- EGCG,    Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate
- in-vitro, Cerv, HeLa
TrxR↓, Trx↓, ROS↑, Dose↑,
2143- Ex,    The association between physical activity and bladder cancer: systematic review and meta-analysis
- Review, Bladder, NA
Risk↓, Dose↝,
2144- Ex,    Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies
- Analysis, NA, NA
Risk↓, Dose?, eff↑,
2145- Ex,    Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies
- Analysis, Var, NA
Risk↓, Dose↝, eff↑,
2149- Ex,    Physical activity and exercise training in cancer patients
- Analysis, Var, NA
eff↑, Dose↑,
2150- Ex,    Roles and molecular mechanisms of physical exercise in cancer prevention and treatment
- Review, Var, NA
eff↓, Dose↝, TumCP↓, Apoptosis↓, ChemoSen↑, chemoP↑,
4075- FA,    Folic acid, ageing, depression, and dementia
- Review, AD, NA
*Mood↑, *cognitive↑, *other↝, *memory↑, *QoL↑, *homoC↝, *other↝, *Dose↝,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2497- Fenb,    In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells
- in-vitro, GBM, NA
Dose?, selectivity↑, TumCD↑, α-tubulin↓,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP↑, ROS↑, cMyc↓, cardioP↑,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
4028- FulvicA,    Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells
- in-vitro, Liver, HUH7
Apoptosis↑, TumCP↓, ROS↑, NO↑, Dose↝, MMP↓, Cyt‑c↑, SOD↓, Catalase↓, GSH↑, lipid-P↑, miR-21↓, miR-22↑,
4026- FulvicA,    Shilajitin Cancer Treatment: Probable Mode of Action
- Review, Var, NA
*Inflam↓, *antiOx↑, Dose↝,
4023- FulvicA,    Shilajit (Mumio) Elicits Apoptosis and Suppresses Cell Migration in Oral Cancer Cells through Targeting Urokinase-type Plasminogen Activator and Its Receptor and Chemokine Signaling Pathways
- in-vitro, Oral, NA
tumCV↓, selectivity↑, Apoptosis↑, uPA↓, TumCMig↓, Dose↝, CXCc↓,
1624- GA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- in-vitro, Cerv, NA
ROS↑, Dose∅, MMP↓, GSH↑,
1954- GamB,    Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase
- in-vitro, HCC, SMMC-7721 cell
AntiTum↑, TrxR↓, TrxR1↓, ROS↑, Apoptosis↑, Dose∅, Dose?,
1955- GamB,    Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
- in-vitro, Pca, NA
ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑,
1636- GAR,    Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation
- Case Report, Obesity, NA
*Dose∅, *other↑,
3721- Gb,    Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice
- Review, AD, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSR↑, *MMP↑, *Inflam↓, *Aβ↓, *memory↑, *Dose↝, *BBB↑, *neuroP↑,
2465- GI,    Effect of daily ginger consumption on platelet aggregation
- Trial, Nor, NA
AntiAg↝, Dose∅,
4307- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models
- in-vivo, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *neuroP↑, *memory↑, *BBB↑, *BDNF↑, *TNF-α↓, *Catalase↑, *IL6↓, *Aβ↓, *GABA↓, *Dose↝,
4308- H2,    A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy
- in-vivo, AD, NA
*BioAv↝, *ROS↓, *p‑tau↓, *Dose↝, *cognitive↑,
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, OS↑, Dose↝, Dose↝, CEA↓, CA125↓, CYFRA21-1↓, SIRT1↓, COX2↓, IL1β↓, IL6↓, TNF-α↓, HMGB1↓, NF-kB↓, EP2↓,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,
2505- H2,    Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
- Trial, CRC, NA
PGC-1α↑, Dose↝, CD8+↑, OS↑,
2506- H2,    Molecular hydrogen suppresses activated Wnt/β-catenin signaling
- in-vivo, Arthritis, NA
*Wnt↓, *β-catenin/ZEB1↓, *Dose↝,
2524- H2,    Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
- Trial, NA, NA
hepatoP↑, ALAT↓, AST↓, Dose↝, Dose↝,
2509- H2,    Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
- in-vitro, Endo, AN3CA - in-vivo, Endo, NA
selectivity↑, mt-ROS↑, ROS↑, TumW↓, GSDMD↑, Pyro↑, Dose↝, eff↓, TumVol↓,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, asthmatic, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
2513- H2,    Hydrogen therapy: from mechanism to cerebral diseases
- Review, Stroke, NA
*BBB?, *antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Dose↝,
3152- H2,  VitC,  Rad,    Hydrogen and Vitamin C Combination Therapy: A Novel Method of Radioprotection
- in-vitro, Nor, HUVECs - in-vivo, NA, NA
AntiTum↑, OS↑, QoL↑, TumVol↓, radioP↑, Dose↑, Dose↝, eff↑,
2527- H2,    The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats
- in-vivo, Wounds, NA
*Dose↝, *SOD↑, *EGF↑, *antiOx↑, *Inflam↓, *Dose↝,
2530- H2,    Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases
- Case Report, PSA, NA
eff↑, Dose↝, eff↑, IL6↓, eff↑,
1631- HCA,    An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management
- Review, Obesity, NA
*ACLY↓, *toxicity∅, *Dose∅,
1641- HCAs,    Lung cancer induced by Benzo(A)Pyrene: ChemoProtective effect of sinapic acid in swiss albino mice
- in-vitro, Lung, A549 - in-vivo, Lung, NA
AntiCan↑, Igs↓, lipid-P↓, ROS↑, Casp3↑, Casp9↑, ChemoSideEff↓, Dose∅,
1644- HCAs,  PBG,    Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis
- in-vitro, Pca, LNCaP
NF-kB↓, TRAILR↑, Casp8↑, Casp3↑, MMP↓, Dose?,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
1645- HCAs,    Chapter 8 - Hydroxycinnamic Acids: Natural Sources, Biosynthesis, Possible Biological Activities, and Roles in Islamic Medicine
- Review, Nor, NA
Dose∅, ROS⇅, Dose∅,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2873- HNK,    Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
- in-vitro, Nor, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NADPH↑, *Trx1↑, *TrxR1↑, *NRF2↑, *ROS↓, *antiOx↑, *BBB↑, Dose↓,
2079- HNK,    Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway
- in-vitro, Nor, PC12
*toxicity↝, *ROS↓, *ROS↑, *Dose⇅, *BioAv↑, *BioAv↓, *ROS⇅, *SOD↓, *toxicity↑,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
2180- itraC,    Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
- Review, Var, NA
Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, eff↑,
1917- JG,    Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion
- in-vitro, AML, HL-60
selectivity↑, LC3I↑, LC3II↑, Beclin-1↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,
4011- K+,    Sodium and potassium intakes among US adults: NHANES 2003–2008
- Analysis, NA, NA
*Dose↓, *eff↑, *BP↓,
4005- K+,    Potassium
- Review, Nor, NA - Review, Stroke, NA
*Risk↓, *Dose↝, *Risk↓, *BMD↑, *glucose↓,
1534- LT,  Api,  EGCG,  RES,    Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, PC, Bxpc-3
TumCP↓, Apoptosis↑, eff↓, *toxicity↑, Dose?, eff↓, eff↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1↓, *FASN↓, *ACC↓,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,
1716- Lyco,    Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species
- in-vitro, AML, RAW264.7
antiOx↑, lipid-P↓, ROS↑, Dose↑,
1713- Lyco,    Lycopene: A Potent Antioxidant with Multiple Health Benefits
- Review, Nor, NA
*antiOx↑, *ROS⇅, *Dose↝, *eff↑, *LDL↓, *RenoP↑, *Inflam↓, neuroP↑, Rho↓,
1711- Lyco,    Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review
- Review, Var, NA
ROS↑, Dose↓, Dose↑, antiOx↑, P450↓, TNF-α↓, IL1β↓, IL12↓,
2644- MCT,    The Effects of Medium-Chain Triglyceride Oil Supplementation on Endurance Performance and Substrate Utilization in Healthy Populations: A Systematic Review
- Review, Nor, NA
*KeyT↑, *Dose↝, eff↑,
1783- MEL,    The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials
- Review, Var, NA
Dose∅, Remission↑, OS↑, radioP↑,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1779- MEL,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1778- MEL,    Melatonin: a well-documented antioxidant with conditional pro-oxidant actions
- Review, Var, NA - Review, AD, NA
*ROS↓, *antiOx↓, ROS↑, selectivity↑, Dose↑, *mitResp↑, *ATP↑, *ROS↓, eff↑, ROS↑, Dose↑, *toxicity∅, ROS↑, eff↓, ROS↝, Dose↑, other↑,
1776- MEL,    Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis
- Review, NA, NA
Remission↑, OS↑, neuroP↑, VEGF↓, KISS1↑, TumCP↓, ChemoSideEff↓, radioP↑, Dose∅, *ROS↓, DNArepair↑, ROS↑,
2385- MET,    Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model
- in-vitro, AD, H4 - in-vitro, NA, HEK293 - in-vivo, NA, NA - in-vitro, NA, SH-SY5Y
*HK2↓, *PKM2↓, *Dose↝, IKKα↑, memory↑, p‑Hsc70↑, APP↓,
2486- metroC,  capec,    Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases
- Case Report, HCC, NA
OS↑, eff↝, Dose↝, AFP↓, Dose↝, TumVol↓, AFP↓,
2488- metroC,    Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma
- in-vitro, HCC, HUH7 - in-vivo, HCC, NA
TumCG↓, toxicity↓, OS↑, TSP-1↑, Dose↓, Dose↓,
2489- metroC,  capec,    Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinoma
- Case Report, HCC, NA
Dose↝, OS↑, TumVol↓, AFP↓,
2250- MF,  MNPs,    Confronting stem cells with surface-modified magnetic nanoparticles and low-frequency pulsed electromagnetic field
- Review, NA, NA
*Ca+2↑, *Dose↝, *BioAv↓,
4571- MF,    Magnetic Fields and Reactive Oxygen Species
- Review, NA, NA
*ROS⇅, *ETC↓, Dose↝, Dose↝,
4425- MF,  doxoR,    Brief Magnetic Field Exposure Stimulates Doxorubicin Uptake into Breast Cancer Cells in Association with TRPC1 Expression: A Precision Oncology Methodology to Enhance Chemotherapeutic Outcome
- in-vitro, BC, 4T1 - in-vitro, BC, MCF-7
ChemoSen↑, TRPC1↑, Dose↓, selectivity↑,
4349- MF,    Long-term effect of full-body pulsed electromagnetic field and exercise protocol in the treatment of men with osteopenia or osteoporosis: A randomized placebo-controlled trial
- Trial, ostP, NA
*BMD↑, *Pain↓, *QoL↑, *toxicity↓, *Dose↝, *Inflam↓,
4355- MF,    Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism
- in-vitro, Nor, C2C12
*mt-OCR↑, *mt-ROS↑, *ECAR↑, *Dose↝, *Ca+2↑, *ATP↑, *other↑, *eff↓, *eff↝,
3473- MF,    Therapeutic use of pulsed electromagnetic field therapy reduces prostate volume and lower urinary tract symptoms in benign prostatic hyperplasia
- Human, BPH, NA
*Inflam↓, *Dose↝, *other?,
4102- MF,    Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients
- Human, Stroke, NA
*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,
4103- MF,    Comparing the Effects of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields With Different Values on Learning, Memory, Anxiety, and β-amyloid Deposition in Adult Rats
- in-vivo, NA, NA
*Dose↝, *memory↑, *ROS↑, *MDA↑,
4094- MF,    EMAGINE-Study protocol of a randomized controlled trial for determining the efficacy of a frequency tuned electromagnetic field treatment in facilitating recovery within the subacute phase following ischemic stroke
- Study, Stroke, NA
*neuroP↑, *Dose↝,
4095- MF,    Frequency-tuned electromagnetic field therapy improves post-stroke motor function: A pilot randomized controlled trial
- Trial, Stroke, NA
*Dose↝, *motorD↑,
4096- MF,    Extremely Low‐Frequency and Low‐Intensity Electromagnetic Field Technology (ELF‐EMF) Sculpts Microtubules
- in-vitro, AD, NA
*p‑tau↓, *neuroP↑, *Dose↝,
4097- MF,    Theta Frequency Electromagnetic Stimulation Enhances Functional Recovery After Stroke
- Trial, Stroke, NA
*motorD↑, *eff↑, *Dose↝,
4098- MF,    Extremely low frequency electromagnetic field (ELF-EMF) reduces oxidative stress and improves functional and psychological status in ischemic stroke patients
- Trial, Stroke, NA
*antiOx↑, *cognitive↑, *Dose↝,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
4119- MF,    Therapeutic potential and mechanisms of repetitive transcranial magnetic stimulation in Alzheimer’s disease: a literature review
- Review, AD, NA
*cognitive↑, *memory↑, *motorD↑, *eff↑, *eff↑, *Dose↝, *Dose↝, *Dose↝, *BDNF↑, *Aβ↓, *eff↑,
4015- MF,    Evaluation of the PTEN and circRNA-CDR1as Gene Expression Changes in Gastric Cancer and Normal Cell Lines Following the Exposure to Weak and Moderate 50 Hz Electromagnetic Fields
- in-vitro, GC, AGS - in-vitro, Nor, HU02
*PTEN↑, PTEN↓, Dose↝,
3740- MF,    Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *Dose↝, *Aβ↓, *PSD95↑,
4148- MF,    Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients
- Human, Stroke, NA
*neuroP↑, *BDNF↑, *Dose↝,
1762- MF,  Fe,    Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane
- in-vitro, RCC, NA
Dose∅, Apoptosis↑, Casp↑, tumCV↓, Casp3↑, Casp7↑, Ca+2↑, Cyt‑c↑,
491- MF,    Pre-exposure of neuroblastoma cell line to pulsed electromagnetic field prevents H2 O2 -induced ROS production by increasing MnSOD activity
- in-vitro, neuroblastoma, SH-SY5Y
*Dose∅, *ROS↓,
192- MF,    The use of magnetic fields in treatment of patients with rheumatoid arthritis. Review of the literature
- Review, Arthritis, NA
*Dose↝,
185- MFrot,  MF,    Case Report: End-Stage Recurrent Glioblastoma Treated With a New Noninvasive Non-Contact Oncomagnetic Device
- Human, GBM, NA
TumVol↓, Dose↝, cognitive↑,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
516- MFrot,  immuno,  MF,    Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growth
- vitro+vivo, GBM, U87MG
TumCP↓, Apoptosis↑, TumCMig↓, ROS↑, PD-L1↑, TumVol↓, eff↑, *toxicity∅, eff↑, *toxicity∅, Dose↝, tumCV↓, TumCI↓,
4569- MFrot,    Case Report: A new noninvasive device-based treatment of a mesencephalic H3 K27M glioma
- Case Report, GBM, NA
Dose↝, Dose↑, Dose↑, OS↑, toxicity↓, ETC↓, ROS↑,
1737- MFrot,  Fe,  MF,    Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma Cells
- in-vitro, MB, A375
Dose∅, tumCV↓,
3849- MSM,    Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing
- Human, Nor, NA
*Dose↝, *AntiAge↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
3846- MSM,    Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy
- Human, NA, NA
*Dose↝, *BBB↑, *eff↓,
2484- mushLions,    Neurotrophic and Neuroprotective Effects of Hericium erinaceus
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*eff↑, *BBB↑, *Dose↝, *neuroP↑, *cognitive↑, *toxicity∅,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
2934- NAD,    The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
- Trial, Nor, NA
*Dose↑, *Strength↑,
2931- NAD,    NAD+ Repletion Rescues Female Fertility during Reproductive Aging
- in-vivo, Nor, NA
*eff↑, *SIRT2↑, *other↑, *Dose↝,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
4976- Nimb,    Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition
- vitro+vivo, PC, NA
ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,
4626- OLE,    A Comprehensive Review on the Anti-Cancer Effects of Oleuropein
- Review, Var, NA
Risk↓, Dose↑, TumCP↓, NF-kB↓, COX2↓, Akt↓, P53↑, BAX↑, Bcl-2↓, HIF-1↓, ROS↑, HO-1↑, chemoP↑, TumCCA↑, FASN↓,
1812- Oxy,    Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer
- in-vitro, Lung, A549 - in-vivo, Lung, NA - in-vitro, NA, BEAS-2B
TumCG↓, CD31↑, P53↓, Dose∅, other↑, Apoptosis↑, Hif1a↑, selectivity↑,
2038- PB,    A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies
- Trial, Var, NA
Dose∅, *toxicity↝, BioAv↑, SD↑,
2025- PB,    Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate
- Case Report, GBM, NA
Dose↝, OS↑,
2026- PB,    Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: A dose escalation and pharmacologic study
- Trial, GBM, NA
Dose↝, Dose↑, Dose↝, OS↑, HDAC↓, TumCCA↑, P21↑, other↝, BioAv↑, eff↑,
2027- PB,    Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors
- Trial, Var, NA
TumCG↓, Dose↝, toxicity↓, Dose↝, HDAC↓, OS↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,
2382- PBG,    Integration with Transcriptomic and Metabolomic Analyses Reveals the In Vitro Cytotoxic Mechanisms of Chinese Poplar Propolis by Triggering the Glucose Metabolism in Human Hepatocellular Carcinoma Cells
- in-vitro, HCC, HepG2
TumCP↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GLUT1↓, GLUT2↓, LDHA↓, HK2↓, PKM2↓, PFK↓, Dose↝,
1665- PBG,    Evidence on the Health Benefits of Supplemental Propolis
- Review, Nor, NA
*antiOx↑, *Inflam↓, *toxicity↑, *Dose?,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2↓, eff↑, Bax:Bcl2↑,
1648- PBG,    Contribution of Green Propolis to the Antioxidant, Physical, and Sensory Properties of Fruity Jelly Candies Made with Sugars or Fructans
- Review, Nor, NA
Dose∅, Dose∅, eff↓, antiOx↑,
1647- PBG,  CA,    Antioxidant Properties and Phenolic Composition of Greek Propolis Extracts
- Analysis, Nor, NA
Dose?, antiOx↑, other↑,
1685- PBG,    Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells
- in-vitro, BC, MCF-7
ANXA7↑, ROS↑, NF-kB↓, MMP↓, selectivity↑, Dose⇅, ROS⇅,
1674- PBG,  SDT,  HPT,    Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
- in-vitro, PC, PANC1 - in-vitro, Nor, H6c7
tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,
1677- PBG,    Propolis Inhibits UVA-Induced Apoptosis of Human Keratinocyte HaCaT Cells by Scavenging ROS
- in-vitro, Nor, HaCaT
*Dose∅, *AP-1↓, *MMP↑, *Casp3↓, *ROS↓,
4938- PEITC,    Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers
- Trial, Nor, NA
*Risk↑, *P450↓, *BioAv↑, *BioAv↑, *BioAv↑, *Dose↝, Dose↝,
4925- PEITC,    PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells
- in-vitro, OS, NA
tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,
4924- PEITC,    Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial
- Trial, Oral, NA
QoL↑, P53↑, OS↑, Cyt‑c↝, other↝, ROS↑, selectivity↑, P21↑, TumCCA↑, Dose↝, BioAv↑, Weight↑, chemoP↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4963- PEITC,    Doses_of_b_-_Phenylethyl_isothiocyanate_PEITC_Induce_Cell_Cycle_Arrest_and_Retard_Growth_of_p53_Mutated_Oral_Cancer_In_Vitro_and_In_Vivo">Sensory Acceptable Equivalent Doses of β - Phenylethyl isothiocyanate (PEITC) Induce Cell Cycle Arrest and Retard Growth of p53 Mutated Oral Cancer In Vitro and In Vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
Dose↝, selectivity↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
4954- PEITC,    Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
- vitro+vivo, Ovarian, SKOV3
ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,
1774- PG,    Geno- and cytotoxicity of propyl gallate food additive
- in-vitro, Lung, A549
TumCG↓, Dose∅, DNAdam↑,
1764- PG,  Cu,    DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II)
- in-vitro, Nor, GM05757
*DNAdam↑, *ROS↑, *Dose∅, *DNAdam∅,
1768- PG,    Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCG↓, TumCCA↓, Dose∅, Bcl-2↓, cl‑PARP↑, MMP↓, Casp3↑, Casp8↑,
1765- PG,    Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-6
TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,
1939- PL,    Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP↑, Dose↝,
2963- PL,    Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease
- in-vitro, AD, HEK293
*SIRT1↑, *cognitive↑, *Aβ↓, *Inflam↓, *neuroP↑, memory↑, Dose↓, NAD↑,
2968- PL,  Chit,    Preparation of piperlongumine-loaded chitosan nanoparticles for safe and efficient cancer therapy
- in-vitro, GC, AGS
eff↑, Dose↝, ROS↑, BioAv↑,
3916- PS,    The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study
- Human, AD, NA
*memory↑, *cognitive↑, *BP↓, *Dose↝, *eff↑,
3931- PTS,    Pterostilbene Protects against Osteoarthritis through NLRP3 Inflammasome Inactivation and Improves Gut Microbiota as Evidenced by In Vivo and In Vitro Studies
- in-vivo, Arthritis, NA
*Inflam↓, *NLRP3↓, *GutMicro↑, *lipid-P↓, *ROS↓, *Cartilage↑, *IL6↓, *MMP13↓, *Dose↝,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
2334- RES,    Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy
- Review, Var, NA
GLUT1↓, GlucoseCon↓, lactateProd↓, Akt↓, mTOR↓, Dose↝, SIRT6↑, PKM2↓, HK2↓, PFK1↓, ChemoSen↑,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
2650- RES,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, Dose↝, NRF2↑, NAF1↓, ChemoSen↑, BioAv↓,
2565- RES,    https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2007.06788.x
- in-vitro, NA, NA - in-vivo, NA, NA
AntiAg↑, TXA2↑, PKCδ↑, Dose↝,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3078- RES,    The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
- Review, Pca, NA
*ROS↓, ROS↑, DNAdam↑, Apoptosis↑, Hif1a↑, Casp3↑, Casp9↑, Cyt‑c↑, Dose↝, MMPs↓, MMP2↓, MMP9↓, EMT↓, E-cadherin↑, N-cadherin↓, AR↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3056- RES,    Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice
- in-vivo, Nor, NA
*AMPK↑, *P21↑, *Dose↓, *chemoPv↑,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27↑, TumCCA↑, ChemoSen↑, COX2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
4357- RF,    Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies
- Review, Var, NA
other↝, Dose↝, AntiTum↑, Ca+2↝, eff↝,
3621- RosA,    Short-Term Study on the Effects of Rosemary on Cognitive Function in an Elderly Population
- Trial, AD, NA
*cognitive↑, *Dose↝, *BioAv↑,
1742- RosA,    Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage
- Analysis, Var, NA
ROS↑, eff↑, eff↑, eff↑, eff↑, eff↓, Dose↝, Dose↝,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
2548- SDT,    Sonoporation, a Novel Frontier for Cancer Treatment: A Review of the Literature
- Review, Var, NA
sonoP↑, Dose↝, eff↓, Dose↝, BioEnh↑, toxicity↝,
2537- SDT,    Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers
- Review, Var, NA
Dose↝, eff↑, eff↑, eff↑, eff↑,
2536- SDT,    Sonodynamic Therapy: Rapid Progress and New Opportunities for Non-Invasive Tumor Cell Killing with Sound
- Review, Var, NA
ROS↑, eff↑, Dose?,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,
2551- SDT,    Sonoporation: Past, Present, and Future
- Review, Var, NA
other↝, sonoP↑, Dose↝,
2141- Se,    Selenium and cancer risk: Wide-angled Mendelian randomization analysis
- Review, NA, NA
Dose↝, Risk↝,
2142- Se,    A U-shaped association between selenium intake and cancer risk
- Review, NA, NA
*Risk↝, Dose↝, *Risk↓,
1697- Se,  Calc,    Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland
- Human, CRC, NA
Risk↓, Risk↓, Dose∅, AntiCan↑,
1688- Se,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,
1689- Se,    Selenium and breast cancer - An update of clinical and epidemiological data
- Analysis, BC, NA
OS↑, eff↑, Dose∅, *toxicity↝, eff↑,
1690- Se,    Selenium and cancer: a story that should not be forgotten-insights from genomics
- Review, Var, NA
Dose↓, other↝,
1695- Se,    Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study
- Trial, CRC, NA
Risk↓, selm↑, Dose↓, antiOx↑, Dose↑, Dose↝,
1701- Se,    An Assessment of Serum Selenium Concentration in Women with Ovarian Cancer
- Human, Ovarian, NA
Risk↓, Risk↓, Dose∅,
1700- Se,    Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor Cancers
- Review, Var, NA
Dose↝, Risk↑, Dose↝, Risk↓,
1699- Se,    Vegetarianism and colorectal cancer risk in a low-selenium environment: effect modification by selenium status? A possible factor contributing to the null results in British vegetarians
- Analysis, CRC, NA
Dose↑, eff↓, Dose↓,
4608- Se,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,
4615- Se,  Rad,    Selenium as an adjuvant for modification of radiation response
- Review, Nor, NA
*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,
4614- Se,  Rad,    Updates on clinical studies of selenium supplementation in radiotherapy
- Review, Nor, NA
*toxicity∅, Risk↓, *selenoP↑, *ROS↓, *DNAdam↓, *QoL↑, *radioP↑, *Dose↝,
4612- Se,  Rad,    Histopathological Evaluation of Radioprotective Effects: Selenium Nanoparticles Protect Lung Tissue from Radiation Damage
- in-vivo, Nor, NA
*radioP↑, *Inflam↓, *antiOx↑, *Dose↝, *DNAdam↓, *ROS↓, *SOD↑, *GPx↑, *Dose↝, *eff↑,
4611- Se,  Rad,    Radioprotective Effect of Selenium Nanoparticles: A Mini Review
- Review, Var, NA
*antiOx↑, *Inflam↓, *radioP↑, *ROCK1↓, *DNAdam↓, *Apoptosis↓, *RadioS↑, *Dose↝,
4604- Se,  SNP,  Chit,    The ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino rats
- in-vivo, Nor, NA
*Dose↝, *GSH↑, *SOD↑, *toxicity↓,
4605- Se,    Selenium nanoparticles: An insight on its Pro-oxidant andantioxidant properties
- Review, NA, NA
*antiOx↑, *selenoP↑, *Dose↝, *toxicity↓, ROS↑, ER Stress↑,
4606- Se,  VitC,    Antibacterial and anti-biofilm efficacy of selenium nanoparticles against Pseudomonas aeruginosa: Characterization and in vitro analysis
- in-vitro, NA, NA
*Dose↝, *Dose↝, *Bacteria↓,
4607- Se,  SNP,    A Review on synthesis and their antibacterial activity of Silver and Selenium nanoparticles against biofilm forming Staphylococcus aureus
- Review, NA, NA
*Bacteria↓, *eff↑, ROS↑, *Dose↝, *eff↑, toxicity↝, *Sepsis↓, *other↝, eff↑,
4609- Se,    Physiological Benefits of Novel Selenium Delivery via Nanoparticles
- Review, Var, NA - Review, IBD, NA - Review, Diabetic, NA
*selenoP↑, Risk↓, AntiCan↑, ROS↑, *Dose↝, *toxicity↓, *BioAv↑, *GutMicro↑, *other↓,
4718- Se,    High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer
- in-vitro, Ovarian, NA
TumCP↑, ROS↑, GPx↓, lipid-P↑, Ferroptosis↑, Dose↑,
4716- Se,    Selenium Substitution During Radiotherapy of Solid Tumours – Laboratory Data from Two Observation Studies in Gynaecological and Head and Neck Cancer Patients
- in-vivo, HNSCC, NA
Dose↝, *GPx↑, *ROS↓,
4752- Se,  CUR,  Chemo,    Curcumin-Modified Selenium Nanoparticles Improve S180 Tumour Therapy in Mice by Regulating the Gut Microbiota and Chemotherapy
- in-vitro, Cerv, HeLa - in-vitro, sarcoma, S180
tumCV↓, ROS↑, *GutMicro↑, BioAv↑, other↝, Dose↝,
4751- Se,  Chemo,    Selenium Protects Against Toxicity Induced by Anticancer Drugs and Augments Antitumor Activity: A Highly Selective, New, and Novel Approach for the Treatment of Solid Tumors
- in-vivo, Var, NA
Dose↝, ChemoSen↑, chemoP↑,
4748- Se,  Chemo,  antiOx,    Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in gastric cancer patients receiving adjuvant oxaliplatin and capecitabine after gastrectomy: a retrospective pilot study
- Trial, GC, NA
toxicity↓, chemoP∅, *neuroP↑, *Dose↝,
4742- Se,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
4726- Se,  Oxy,    Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma
- in-vivo, HCC, NA
eff↝, NRF2↓, p‑p38↑, Apoptosis↑, eff↑, TumVol↓, other↝, toxicity↓, Dose↝, NRF2↝, HO-1↓, Catalase↓, SOD↓, e-pH↓, pH∅, MAPK↑, eff↑,
4740- Se,    Optimising Selenium for Modulation of Cancer Treatments
- Review, Var, NA
*selenoP↑, *Dose↓, Risk↓, *toxicity↝, Dose↑, chemoP↑, radioP↑,
4739- Se,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,
4734- Se,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,
4757- Se,  Chemo,    The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients
- Trial, NA, NA
Dose↝, *ALP↓, chemoP↑,
4495- Se,    Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
- Study, CRC, NA
Risk↓, Dose↝,
4498- Se,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
4502- Se,    Modulatory effects of selenium nanoparticles on gut microbiota and metabolites of juvenile Nile tilapia (Oreochromis niloticus) by microbiome-metabolomic analysis
- in-vivo, Nor, NA
*GutMicro↑, *Dose↝, *other↝, *toxicity↓, *BioAv↑, *Bacteria↓,
4446- Se,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
4441- Se,    The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures
- Review, Nor, NA
*ROS↓, *hepatoP↑, *selenoP↑, *ALAT↓, *AST↓, *GSH↑, *GPx↑, *TNF-α↓, *IL6↓, *NF-kB↓, *p65↓, *Dose⇅,
4470- Se,  Chit,    Synthesis and cytotoxic activities of selenium nanoparticles incorporated nano-chitosan
- in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7
Dose↝, AntiCan↑, eff↑,
4467- Se,  VitC,  Chit,    Nano-chitosan-coated, green-synthesized selenium nanoparticles as a novel antifungal agent against Sclerotinia sclerotiorum in vitro study
- Study, NA, NA
*Dose↝, *Dose↝,
4465- Se,  VitC,    Selenium nanoparticles: Synthesis, in-vitro cytotoxicity, antioxidant activity and interaction studies with ct-DNA and HSA, HHb and Cyt c serum proteins
- Study, NA, NA
*other↝, *eff↑, AntiCan↑, *Dose↝, *BioAv↑, *other↝,
4463- Se,  VitC,    Selenium nanoparticles: Synthesis, characterization and study of their cytotoxicity, antioxidant and antibacterial activity
- Study, Nor, NA
Dose↝,
4461- Se,  VitC,    Synthesis, Characterization, and Cytotoxic Evaluation of Selenium Nanoparticles
*Dose?,
4457- Se,    Selenium nanoparticles: a review on synthesis and biomedical applications
- Review, Var, NA - NA, Diabetic, NA
*BioAv↑, *toxicity↓, *eff↑, chemoPv↑, *Inflam↓, antiOx↑, *selenoP↑, *ROS↓, *Dose↝, AntiCan↑, *Bacteria↓, eff↑, DNAdam↑, selectivity↑, *eff↑,
4491- Se,  Chit,  VitC,    Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
- Study, NA, NA
*ROS↓, *selenoP↑, *antiOx↑, *Inflam↓, *Risk↓, *toxicity↓, AntiTum↑, Dose↝,
4458- Se,    Selenium Nanoparticles for Antioxidant Activity and Selenium Enrichment in Plants
*Dose↝, *eff↑, *Dose↝,
4459- Se,  VitC,    Nano and mesosized selenium and its synthesis using the ascorbic acid route
*eff↑, *Dose↝, *Dose↝,
4460- Se,  VitC,    Ascorbic acid-mediated selenium nanoparticles as potential antihyperuricemic, antioxidant, anticoagulant, and thrombolytic agents
Dose?,
4462- Se,  VitC,    Selenium nanoparticles: influence of reducing agents on particle stability and antibacterial activity at biogenic concentrations
- Study, Nor, NA
*Dose↝, *Bacteria↓,
2552- SFN,  Chemo,    Chemopreventive activity of sulforaphane
- Review, Var, NA
chemoPv↑, TumCG↓, *ROS↓, *Inflam↓, *Dose↝, *NRF2↑, *HO-1↑, *NQO1↑, NF-kB↓, ROS↑,
2554- SFN,    Sulforaphane (SFN): An Isothiocyanate in a Cancer Chemoprevention Paradigm
- Review, Var, NA
Dose↝, chemoPv↑, *NQO1↑, *GSTA1↑, HDAC↓, NF-kB↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
2406- SFN,    Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach
- Review, Pca, NA
HK2↓, PKM2↓, LDHA↓, Glycolysis↓, LAMP2↑, Hif1a↓, DNAdam↓, DNArepair↓, Dose↝,
1725- SFN,    Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
- Review, Var, NA
*toxicity∅, AntiCan↑, antiOx↑, NRF2↑, DNMTs↓, HDAC↓, Hif1a↓, VEGF↓, P21↑, TumCCA↑, ac‑H3↑, ac‑H4↑, DNAdam↑, Dose↝,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1501- SFN,    The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
- in-vitro, CRC, T24
Dose↝, NRF2↑, GSH↓, eff↑,
2164- SFN,  dietP,    Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice
- in-vitro, Pca, NA
HDAC↓, Dose↝, Risk↓, TumCP↓, H3↓,
1507- SFN,    Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
- in-vivo, Colon, NA - Human, Nor, NA
TumCG↓, HDAC↓, *BioAv↑, Dose∅, Half-Life∅,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3305- SIL,    Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vivo, NA, NA
TumCP↓, tumCV↓, BAX↑, cl‑PARP↑, Casp9↑, p‑JNK↑, Bcl-2↓, p‑p38↓, p‑ERK↓, *toxicity∅, Dose↝, *hepatoP↑, Inflam↓, AntiCan↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3321- SIL,    Silymarin (Milk thistle)
- Review, AD, NA
*neuroP↝, *Dose↝, *Half-Life?, *BioAv↝, *cognitive↑, *Aβ↓, *Inflam↓, *OS↑, *memory↑,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, NA, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
2306- SIL,  CUR,  RES,  EA,    Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer Treatment
- in-vitro, BC, MDA-MB-231
PKM2↓, Dose↝, Dose↝,
4128- Silicon,    Silicon as Versatile Player in Plant and Human Biology: Overlooked and Poorly Understood
- Review, NA, NA
*other↑, *BMD↑, *Dose↝, *cognitive↑, *Dose?,
4133- Silicon,    Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study
- Study, AD, NA
*Risk↓, *Dose↑, *neuroP↑,
2361- SK,    Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer
- in-vivo, CRC, NA
GutMicro↑, Dose↝, IL1β↓, IL6↓, TNF-α↓, PKM2↓,
2218- SK,    Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
- in-vitro, Nor, HUVECs
*Dose↝, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *Inflam↓, *VCAM-1↓, *ICAM-1↓, *E-sel↓, *ROS↓, *SOD↑, *AMPK↑, *NRF2↑, *HO-1↑, *TNF-α↓, *IL1β↓, *IL6↓,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
305- SNP,    Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer
- Case Report, HNSCC, NA
OS↑, Dose↓, BioAv↝, toxicity↓, Remission↑, other↝, other↝, other↝, Dose↝, BioAv↝,
375- SNP,  ALA,    Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vivo, NA, NA
mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,
2205- SNP,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
2206- SNP,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2834- SNP,  Gluc,    Electrochemical oxidation of glucose on silver nanoparticle-modified composite electrodes
- Study, NA, NA
Dose?,
2835- SNP,  Gluc,    Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
- in-vitro, Liver, HepG2
Dose↝, eff↑, ROS↑, eff↝, eff↑, eff↝, eff↑, eff↝,
4439- SNP,    Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA)
- in-vitro, Cerv, HeLa
ROS↑, lipid-P↑, MMP↓, GSH↓, TumCCA↑, Apoptosis↑, Necroptosis↑, TumCD↑, Dose↝,
4447- SNP,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
4579- SNP,    Response of platelets to silver nanoparticles designed with different surface functionalization
*AntiAg↑, *AntiThr↑, *Dose↝,
4577- SNP,    Characterization of Antiplatelet Properties of Silver Nanoparticles
- vitro+vivo, Stroke, NA
*AntiAg↑, *Bacteria↓, *Dose↝, *Dose↝, *Dose↝, *toxicity↝,
4560- SNP,    Exploiting antidiabetic activity of silver nanoparticles synthesized using Punica granatum leaves and anticancer potential against human liver cancer cells (HepG2)
- in-vitro, Liver, HepG2 - in-vitro, Diabetic, NA
AntiCan↑, Dose↝, *antiOx↑, *AntiDiabetic↑, *Bacteria↓,
4600- SNP,    Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- in-vivo, Nor, NA
*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,
4598- SNP,    In vivo human time-exposure study of orally dosed commercial silver nanoparticles
- in-vivo, Nor, NA
*toxicity∅, *Dose↝, *Dose↝, *BioAv↝, *BioAv↝, *H2O2∅, *IL8∅, *IL1α∅, *IL1β∅, *MCP1∅, *NQO1∅, *BioAv↓,
4582- SNP,    Silver CASRN 7440-22-4 | DTXSID4024305
*Dose↝,
4402- SNP,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4400- SNP,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,
3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Ca+2↓, *neuroP↑, *other↑, *Dose↝, *PKCδ↓, *VGCC↓, *GABA↑,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
2091- TQ,    Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells
- in-vitro, BC, MCF-7 - in-vitro, GC, AGS
Dose↝, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, HSP70/HSPA5↓,
4565- TQ,    Thymoquinone in the clinical treatment of cancer: Fact or fiction?
- Review, BC, NA
Dose↝, TumCCA↑, P21↑, cycD1/CCND1↓, TumCI↑, TumMeta↓, Bcl-2↓, Bcl-xL↓, survivin↓, PTEN↑, Akt↓, P53↑, NF-kB↓, cardioP↑, Dose↝,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
4854- Uro,    Urolithins: Emerging natural compound targeting castration-resistant prostate cancer (CRPC)
- Review, Pca, NA
AR↓, ROS↓, Apoptosis↑, selectivity↑, Dose↑, MDA↓, SOD↑, GPx↑, ROS↑, Casp3↑, Casp9↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *eff↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1↓, *MIP‑1α↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4312- VitB1/Thiamine,    Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease
- Review, AD, NA
*eff↑, *cognitive↑, *memory↑, *GlucoseCon↑, *Aβ↓, *Inflam↓, *antiOx↑, *p‑tau↓, *AGEs↓, *Dose↝,
4049- VitB1/Thiamine,    Vitamin B1 (thiamine) and dementia
- Review, AD, NA
*memory↑, *p‑tau↓, *cognitive↑, *Dose↝, *Dose↓, *Aβ↓, *other↝, *eff↑, *eff↑,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
4325- VitB5,    Localized Pantothenic Acid (Vitamin B5) Reductions Present Throughout the Dementia with Lewy Bodies Brain
- Study, AD, NA - Study, Park, NA
*Risk↑, *Dose↝, *Dose↓, *other↝,
4329- VitB5,    Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model
- in-vivo, AD, NA
*Aβ↓, *Mood↑, *neuroP↑, *Inflam↓, *TNF-α↓, *BBB↝, *other↝, *Dose↝,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,
1819- VitC,  VitK3,    The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy
- Review, Var, NA
Dose?, TumCD↑, selectivity↑, H2O2↑, ROS↑, DNAdam↑,
596- VitC,    High-Dose Vitamin C in Advanced-Stage Cancer Patients
- Review, NA, NA
ChemoSideEff↓, ROS↑, H2O2↑, Fenton↑, Hif1a↝, Dose↑, BioAv↓, Dose↝, Half-Life↝, IL1β↓, IL2↓, IL8↓, TNF-α↓,
2485- VitC,  TACE,    High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
- Case Report, HCC, NA
ROS↑, Dose↝, Dose↝, TumCG↓, Remission↑,
3102- VitC,    Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
- Review, Var, NA - Review, Stroke, NA
*radioP↑, *Dose↝, ROS↑, *neuroP↑, other↓, *ROS↓, *MMP↑,
1738- VitD3,    VITAL study: an incomplete picture?
- Trial, Var, NA
AntiCan↑, *BioAv↓, Dose↑,
1739- VitD3,    Effect of Vitamin D3 Supplements on Development of Advanced Cancer
- Trial, Var, NA
AntiCan↑, Dose↝, Risk↓, TumCP↓, Inflam↓, eff∅,
1741- VitD3,    Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging
- Review, Var, NA
*Inflam↓, *antiOx↑, *eff↑, *ROS↓, *NRF2↑, *GPx↑, *Dose↝, Dose↑,
2171- VitD3,    Vitamin D and the Immune System
- Analysis, Nor, NA
eff↑, Dose↝, eff↝, eff↑, eff↑,
4088- VitE,    Vitamin E and Alzheimer’s Disease—Is It Time for Personalized Medicine?
- Review, AD, NA
*antiOx↑, *neuroP↑, *Dose↓, *cognitive↑, *other↝,
4079- VitE,  VitC,    Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance
- Review, AD, NA
*neuroP↑, *antiOx↑, *Dose↝, *cognitive↑,
2274- VitK2,    Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
- in-vitro, Nor, SH-SY5Y
*Bcl-2↓, *BAX↑, *MMP↑, *ROS↓, *p62↓, *LC3A↑, *Dose↝, *Apoptosis↓, *PINK1↑, *PARK2↑,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,
1815- VitK3,  VitK2,    Vitamin K
- Review, Nor, NA
*Dose↝, BMD↑,
1831- VitK3,  VitK2,    The anticancer effects of vitamin K
- Review, Var, NA
AntiCan↑, Dose∅,
1828- VitK3,  VitC,    Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C
- in-vivo, GBM, NA
eff↑, ROS↑, Dose∅,
1755- WBV,    Reduction of breast cancer extravasation via vibration activated osteocyte regulation
Dose∅, TumMeta↑, eff∅, Piezo1↑, COX2↑, RANKL↓, TumCG∅, tumCV∅, TumCI↓,
1757- WBV,    The Impact of Vibration Therapy Interventions on Skin Condition and Skin Temperature Changes in Young Women with Lipodystrophy: A Pilot Study
- Human, Nor, NA
Dose∅, other↑,
1761- WBV,    Low Intensity Vibration Mitigates Tumor Progression and Protect Bone Quantity and Quality in a Murine Model of Myeloma
- in-vivo, Melanoma, NA
Dose∅, BMD↑, TumCI↓,
1753- WBV,  Ex,    Physical Exercise with or without Whole-Body Vibration in Breast Cancer Patients Suffering from Aromatase Inhibitor—Induced Musculoskeletal Symptoms: A Pilot Randomized Clinical Study
- Trial, BC, NA
Pain↓, Strength↑, QoL↑, Dose∅,
1752- WBV,  Chemo,    Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies – a randomized controlled pilot study
- Trial, Var, NA
*BP∅, eff↑, Dose∅, other↑, *toxicity∅, eff↑,
1754- WBV,    Vibration Therapy for Cancer-Related Bone Diseases
- Review, Var, NA
*BMD↑, *toxicity∅, other↓, Dose↝, Dose↑, eff↑, eff↑, eff↑,
1750- WBV,    Whole body vibration exercise in the management of cancer therapy-related morbidities: A systematic review
- Review, Var, NA
Wmax↑, UrinaryC↑, other↓, other↓, Dose?,
1913- Xyl,    Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Cell Proliferation and Glycolysis of Mice Bearing Orthotopic Xenograft of Oral Cancer
- in-vivo, Oral, NA
TumVol↓, OS↑, PFK↓, toxicity↓, Dose∅, Ki-67↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 401

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 5,  

Redox & Oxidative Stress ⓘ

antiOx↓, 4,   antiOx↑, 14,   antiOx⇅, 1,   Catalase↓, 4,   Catalase↑, 2,   compI↓, 1,   CoQ10↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   ENOX2↓, 2,   ENOX2↑, 1,   Fenton↑, 1,   Ferroptosis↑, 4,   GPx↓, 3,   GPx↑, 5,   GPx1↓, 1,   GPx1↑, 1,   GSH↓, 13,   GSH↑, 6,   GSH/GSSG↓, 2,   GSR↑, 1,   GSTA1↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 6,   mt-H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 4,   HO-2↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 5,   lipidDe↓, 1,   MDA↓, 1,   MPO↓, 1,   NADH↓, 1,   NADHdeh?, 1,   NAF1↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 10,   NRF2↝, 1,   OXPHOS↓, 3,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   Prx6↑, 1,   PrxI↓, 1,   ROS↓, 13,   ROS↑, 117,   ROS⇅, 5,   ROS↝, 2,   ROS∅, 2,   mt-ROS↑, 6,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↓, 4,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   Trx↓, 2,   TrxR↓, 6,   TrxR1↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   IronCh↑, 1,   selm↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 3,   ATP↓, 7,   ATP↑, 3,   CDC2↓, 1,   CDC25↓, 3,   compIII↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 2,   MEK↓, 1,   mitResp↓, 1,   MMP?, 1,   MMP↓, 36,   MMP↝, 1,   MPT↑, 1,   mtDam↑, 8,   OCR↓, 4,   OCR↑, 1,   PGC-1α↑, 3,   Raf↓, 1,   c-Raf↓, 1,   SDH↓, 2,   XIAP↓, 7,  

Core Metabolism/Glycolysis ⓘ

12LOX?, 1,   12LOX↓, 2,   ACC↑, 1,   ACLY↓, 3,   AKT1↓, 1,   ALAT↓, 2,   ALAT↝, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ANXA7↑, 1,   ATG7↑, 1,   CAIX↑, 1,   citrate↓, 1,   cMyc↓, 7,   CPT1A↓, 1,   CREB↓, 1,   CRM↑, 1,   CYP3A4↓, 2,   ECAR↝, 1,   ECAR∅, 1,   FASN↓, 3,   FASN↑, 2,   FBPase↑, 1,   glucoNG↓, 1,   glucoNG↑, 1,   GlucoseCon↓, 9,   GLUT2↓, 1,   GlutMet↓, 1,   Glycolysis↓, 17,   HK2↓, 10,   KeyT↑, 1,   lactateProd↓, 10,   LDH↓, 6,   LDHA↓, 2,   NAD↑, 1,   NADPH↑, 1,   OAA↑, 1,   PCK1↓, 1,   PDH↓, 1,   p‑PDH↓, 1,   p‑PDH↑, 1,   PDK1?, 2,   PDK1↓, 4,   PDKs↓, 3,   p‑PDKs↓, 1,   PFK↓, 4,   PFK1↓, 3,   PFK2?, 1,   PFK2↓, 1,   PKM2↓, 10,   PPARα↓, 1,   PPARγ↑, 1,   p‑S6K↓, 1,   SIRT1↓, 5,   SIRT1↑, 5,   SREBP1↓, 1,   TCA↓, 2,   TCA↑, 1,   Warburg↓, 7,   β-oxidation↓, 1,  

Cell Death ⓘ

Akt↓, 21,   Akt↑, 1,   p‑Akt↓, 6,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 54,   Apoptosis∅, 1,   mt-Apoptosis↑, 1,   ASK1↑, 1,   ATF2↓, 1,   Bak↑, 4,   BAX↓, 2,   BAX↑, 20,   Bax:Bcl2↑, 7,   Bcl-2↓, 26,   Bcl-2↑, 1,   Bcl-xL↓, 8,   BID↑, 1,   BIM↑, 2,   Casp↓, 1,   Casp↑, 10,   Casp1↓, 1,   Casp2↑, 2,   Casp3↓, 1,   Casp3↑, 43,   cl‑Casp3↑, 2,   Casp7↑, 5,   Casp8↑, 9,   Casp9↓, 1,   Casp9↑, 20,   cl‑Casp9↑, 1,   Chk2↓, 1,   Chk2↑, 2,   CK2↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 21,   Cyt‑c↝, 2,   Diablo↑, 3,   DR4↑, 3,   DR5↑, 7,   Fas↓, 1,   Fas↑, 5,   Ferroptosis↑, 4,   GSDMD↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 3,   IAP2↓, 1,   iNOS↓, 4,   iNOS↑, 1,   JNK↑, 9,   p‑JNK↓, 1,   p‑JNK↑, 3,   MAPK↓, 10,   MAPK↑, 8,   Mcl-1↓, 5,   Mcl-1↑, 1,   MDM2↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   Myc↓, 1,   Myc↑, 1,   Necroptosis↑, 2,   necrosis↑, 2,   NOXA↑, 1,   p27↑, 6,   p38↑, 2,   p‑p38↓, 2,   p‑p38↑, 4,   Paraptosis↑, 1,   PUMA↑, 2,   Pyro↑, 1,   p‑RSK↑, 1,   survivin↓, 13,   Telomerase↓, 9,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 12,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   EF-1α↓, 1,   HER2/EBBR2↓, 3,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 2,   H3↓, 2,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 2,   KISS1↑, 1,   miR-21↓, 2,   other?, 1,   other↓, 4,   other↑, 9,   other↝, 16,   SD↑, 1,   tumCV↓, 20,   tumCV∅, 1,   UrinaryC↑, 1,   Wmax↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 5,   cl‑CHOP↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 9,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   p‑Hsc70↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP70/HSPA5⇅, 1,   HSP90↓, 5,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   ATG5↑, 2,   Beclin-1↑, 3,   LAMP2↑, 2,   LC3B↑, 1,   LC3I↑, 1,   LC3II↑, 5,   LC3s↑, 1,   p62↓, 3,   p62↑, 2,   TumAuto↑, 13,   TumAuto↝, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   CHK1↓, 2,   CHK1↑, 1,   DNA-PK↑, 1,   DNAdam↓, 3,   DNAdam↑, 22,   DNArepair↓, 2,   DNArepair↑, 2,   DNMTs↓, 5,   P53↓, 3,   P53↑, 25,   P53↝, 1,   p‑P53↑, 1,   ac‑P53↑, 1,   PARP↑, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 21,   PCNA↓, 7,   SIRT6↓, 1,   SIRT6↑, 2,   TP53↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 10,   CDK4↓, 11,   CDK4↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 20,   cycE/CCNE↓, 5,   P21?, 1,   P21↓, 1,   P21↑, 22,   RB1↑, 1,   p‑RB1↓, 4,   TumCCA↓, 2,   TumCCA↑, 35,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD133↓, 3,   CD34↓, 1,   CD44↓, 2,   CDK8↓, 1,   CSCs↓, 10,   Diff↓, 1,   Diff↑, 2,   EMT↓, 17,   EMT↑, 1,   EP2↓, 1,   ERK↓, 12,   ERK↑, 3,   p‑ERK↓, 5,   p‑ERK↑, 1,   FOXO↑, 1,   FOXO3↓, 1,   FOXO3↑, 2,   Gli1↓, 2,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 18,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC8↓, 1,   HH↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1↑, 1,   IGF-1R↓, 5,   p‑IGF-1R↓, 1,   IGFBP3↑, 2,   IGFR↓, 1,   Jun↓, 1,   Let-7↑, 1,   mTOR↓, 10,   mTOR⇅, 1,   mTORC1↓, 3,   p‑mTORC1↓, 1,   mTORC2↓, 2,   n-MYC↓, 1,   Nanog↓, 2,   Nestin↓, 2,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH3↓, 2,   OCT4↓, 2,   PI3K↓, 15,   PI3K↑, 1,   Piezo1↑, 1,   PTEN↓, 1,   PTEN↑, 16,   p‑PTEN↓, 1,   RAS↓, 1,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 2,   STAT3↓, 20,   p‑STAT3↓, 3,   p‑STAT3↑, 1,   STAT5↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 30,   TumCG↑, 2,   TumCG⇅, 1,   TumCG∅, 3,   Wnt↓, 10,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

5LO↓, 2,   AntiAg↑, 1,   AntiAg↝, 1,   APP↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 10,   Ca+2↝, 2,   i-Ca+2↓, 1,   CD31↑, 1,   CDKN1C↑, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 11,   FAK↓, 5,   p‑FAK↓, 2,   p‑FAK↑, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   Ki-67↓, 6,   MALAT1↓, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-22↑, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 23,   MMP7↓, 2,   MMP9↓, 27,   MMPs↓, 15,   MUC4↓, 1,   N-cadherin↓, 6,   p‑pax↓, 1,   PDGF↓, 3,   PKCδ↓, 2,   PKCδ↑, 1,   Rho↓, 2,   RIP3↑, 1,   p‑RIP3↑, 1,   SMAD3↓, 1,   Snail↓, 5,   SOX4↓, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 2,   Treg lymp↓, 2,   TRPC1↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCI↓, 16,   TumCI↑, 1,   TumCMig↓, 18,   TumCMig↑, 1,   TumCP↓, 34,   TumCP↑, 2,   TumCP⇅, 2,   TumMeta↓, 20,   TumMeta↑, 3,   Twist↓, 4,   uPA↓, 6,   uPAR↓, 1,   VCAM-1↓, 1,   Vim↓, 8,   Zeb1↓, 4,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 12,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 31,   angioG↑, 2,   EGFR↓, 9,   Endoglin↑, 1,   eNOS↑, 1,   EPR↑, 1,   HIF-1↓, 3,   Hif1a↓, 26,   Hif1a↑, 2,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 1,   NO↑, 3,   p‑PDGFR-BB↓, 1,   PHDs↓, 1,   TXA2↑, 1,   VEGF↓, 26,   VEGFR2↓, 5,  

Barriers & Transport ⓘ

BBB↑, 3,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↑, 1,   NHE1↓, 2,   P-gp↓, 4,   P-gp↑, 1,   sonoP↑, 3,  

Immune & Inflammatory Signaling ⓘ

CCR7↓, 1,   CD14↓, 1,   CD4+↑, 1,   COX1↓, 1,   COX2↓, 27,   COX2↑, 2,   CXCc↓, 1,   CXCR4↓, 6,   FOXP3↓, 1,   HMGB1↓, 1,   IFN-γ↑, 1,   Igs↓, 1,   Igs↑, 2,   IKKα↓, 3,   IKKα↑, 1,   IL1↓, 2,   IL1↑, 2,   IL10↓, 4,   IL10↑, 2,   IL12↓, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 17,   IL8↓, 3,   Imm↑, 2,   INF-γ↑, 1,   Inflam↓, 21,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 1,   M2 MC↓, 1,   MCP1↓, 4,   MIP2↓, 1,   NF-kB↓, 41,   NF-kB↑, 2,   NK cell↑, 5,   p50↓, 2,   p65↓, 4,   PD-L1↓, 2,   PD-L1↑, 2,   PDT+↓, 1,   PGE2↓, 7,   PSA↓, 3,   RANTES↓, 1,   T-Cell↑, 2,   T-Cell↝, 1,   Th1 response↑, 2,   Th2↑, 1,   TLR4↓, 2,   TNF-α↓, 13,   TNF-α↑, 3,  

Cellular Microenvironment ⓘ

NOX↓, 1,   pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 7,   CDK6↓, 3,   CDK6↑, 1,   ER(estro)↓, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 18,   BioAv↑, 19,   BioAv↝, 8,   BioAv∅, 1,   BioEnh?, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 50,   ChemoSen∅, 2,   CYP1A2↓, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 1,   Dose?, 26,   Dose↓, 19,   Dose↑, 38,   Dose⇅, 4,   Dose↝, 152,   Dose∅, 82,   eff↓, 27,   eff↑, 155,   eff↝, 19,   eff∅, 4,   Half-Life↓, 5,   Half-Life↑, 2,   Half-Life↝, 8,   Half-Life∅, 4,   MDR1↓, 1,   P450↓, 3,   RadioS↑, 19,   selectivity↓, 1,   selectivity↑, 66,  

Clinical Biomarkers ⓘ

AFP↓, 3,   ALAT↓, 2,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 7,   ascitic↓, 1,   AST↓, 2,   AST↝, 1,   BG↓, 5,   BMD↑, 2,   CA125↓, 1,   CEA↓, 1,   CYFRA21-1↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 9,   Ferritin↓, 1,   GutMicro↑, 4,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IL6↓, 17,   Ki-67↓, 6,   LDH↓, 6,   Myc↓, 1,   Myc↑, 1,   PD-L1↓, 2,   PD-L1↑, 2,   PSA↓, 3,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 29,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop∅, 1,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 8,   chemoP↑, 20,   chemoP∅, 1,   ChemoSideEff↓, 10,   cognitive↑, 3,   hepatoP↑, 5,   memory↑, 3,   NDRG1↑, 1,   neuroP↑, 8,   OS↑, 35,   Pain↓, 1,   QoL↑, 7,   QoL∅, 2,   radioP↑, 10,   Remission↓, 1,   Remission↑, 8,   RenoP↑, 2,   Risk↓, 32,   Risk↑, 3,   Risk↝, 1,   Strength↑, 1,   toxicity↓, 12,   toxicity↑, 1,   toxicity↝, 7,   toxicity∅, 6,   TumVol↓, 15,   TumW↓, 4,   Weight↑, 3,  

Infection & Microbiome ⓘ

CD8+↑, 4,   Sepsis↓, 2,  
Total Targets: 661

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 3,  

Redox & Oxidative Stress ⓘ

antiOx↓, 3,   antiOx↑, 48,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 18,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 1,   GPx↑, 11,   GPx1↑, 2,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 20,   GSR↑, 3,   GSTA1↓, 1,   GSTA1↑, 2,   GSTs↑, 5,   H2O2↓, 1,   H2O2∅, 2,   HDL↑, 3,   HO-1↑, 11,   lipid-P↓, 14,   MDA↓, 9,   MDA↑, 1,   MPO↓, 2,   NOX4↓, 1,   NQO1↑, 4,   NQO1∅, 1,   Nrf1↑, 1,   NRF2↑, 18,   OXPHOS↑, 1,   PARK2↑, 2,   RNS↓, 2,   ROS?, 1,   ROS↓, 64,   ROS↑, 6,   ROS⇅, 4,   ROS∅, 1,   mt-ROS↑, 1,   SAM-e↑, 1,   selenoP↑, 10,   SOD↓, 1,   SOD↑, 23,   SOD1↑, 3,   SOD2↑, 4,   TAC↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 6,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   ATP↝, 1,   EGF↑, 1,   ETC↓, 1,   mitResp↑, 1,   MMP↓, 1,   MMP↑, 7,   mtDam↓, 1,   mt-OCR↑, 1,   PGC-1α↑, 1,   PINK1↑, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ACLY↓, 1,   ACLY∅, 1,   ALAT↓, 6,   AMP↓, 1,   AMPK↑, 4,   p‑CREB↑, 1,   ECAR↑, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 2,   HK2↓, 1,   homoC↓, 1,   homoC↝, 1,   KeyT↑, 1,   LDH↓, 1,   LDH↑, 1,   LDL↓, 4,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 1,   PGC1A↑, 1,   PKM2↓, 1,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↓, 1,   SIRT1↑, 4,   SIRT2↑, 2,   SREBF2↓, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↑, 2,   Apoptosis↓, 4,   BAX↓, 2,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp3↓, 3,   cl‑Casp3↓, 1,   iNOS↓, 6,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↑, 3,   p‑MAPK↓, 1,   p38↓, 2,   p38↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 2,   AntiThr↑, 1,   HATs↓, 1,   other?, 1,   other↓, 4,   other↑, 6,   other↝, 16,   other∅, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes ⓘ

LC3A↑, 1,   MitoP↓, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 7,   DNAdam↑, 1,   DNAdam∅, 1,   GADD45A↑, 1,   p16↓, 1,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,   P21↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   ERK↓, 1,   ERK↑, 1,   Gli1↑, 1,   GSK‐3β↓, 1,   HDAC↑, 1,   HMGCR↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   IGF-1R↓, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   n-MYC↑, 1,   neuroG↑, 1,   OCT4↓, 1,   PI3K↑, 2,   PTEN↓, 1,   PTEN↑, 2,   Shh↑, 1,   STAT↓, 1,   STAT3↓, 1,   VGCC↓, 1,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 5,   AP-1↓, 4,   APP↓, 1,   Ca+2?, 1,   Ca+2↓, 4,   Ca+2↑, 3,   Ca+2↝, 2,   Cartilage↑, 4,   CDK5↓, 1,   E-sel↓, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP2↑, 1,   MMP9↓, 3,   PKCδ↓, 1,   PKCδ↑, 1,   Rho↓, 1,   ROCK1↓, 3,   serineP↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   VCAM-1↓, 4,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,   NO↑, 1,   PDGFR-BB↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB?, 1,   BBB↑, 16,   BBB↝, 1,   GLUT4↑, 1,   OATPs↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 9,   CRP↓, 2,   CTSZ↓, 1,   ICAM-1↓, 5,   IFN-γ↓, 1,   IL1↓, 4,   IL10↑, 2,   IL12↓, 1,   IL18↓, 1,   IL1α↓, 1,   IL1α∅, 1,   IL1β↓, 9,   IL1β∅, 1,   IL2↓, 2,   IL22↓, 1,   IL4↓, 1,   IL4↑, 2,   IL5↑, 1,   IL6↓, 19,   IL8↓, 5,   IL8∅, 1,   Imm↑, 4,   Inflam↓, 54,   JAK↓, 1,   MCP1↓, 3,   MCP1∅, 1,   MIP‑1α↓, 1,   NF-kB↓, 18,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p65↓, 1,   PGE2↓, 4,   PGE2↑, 1,   RANTES↓, 1,   TNF-α↓, 25,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 6,   BChE↓, 1,   BDNF↑, 10,   ChAT↑, 1,   GABA↓, 1,   GABA↑, 1,   MAOA↓, 2,   PSD95↑, 1,   tau↓, 5,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 19,   BACE↓, 1,   MAOB↓, 1,   NLRP3↓, 3,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,   testos↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv?, 1,   BioAv↓, 23,   BioAv↑, 27,   BioAv↝, 17,   BioEnh↑, 1,   Dose?, 4,   Dose↓, 6,   Dose↑, 13,   Dose⇅, 3,   Dose↝, 124,   Dose∅, 10,   eff↓, 4,   eff↑, 44,   eff↝, 2,   Half-Life?, 1,   Half-Life↓, 5,   Half-Life↑, 3,   Half-Life↝, 9,   Half-Life∅, 3,   P450↓, 2,   P450↑, 2,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 6,   BG↓, 2,   Bil↑, 1,   BMD↑, 5,   BMPs↑, 1,   BP↓, 3,   BP↝, 1,   BP∅, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 2,   GutMicro↑, 10,   hs-CRP↓, 1,   IL6↓, 19,   Ki-67↓, 1,   LDH↓, 1,   LDH↑, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 5,   AntiCan↑, 2,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 11,   chemoP↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 32,   hepatoP↓, 1,   hepatoP↑, 16,   memory↑, 24,   Mood↑, 2,   motorD↓, 1,   motorD↑, 5,   neuroP↑, 40,   neuroP↝, 1,   OS↑, 4,   Pain↓, 4,   QoL↑, 5,   radioP↑, 9,   RenoP↑, 5,   Risk↓, 12,   Risk↑, 2,   Risk↝, 1,   Strength↑, 4,   toxicity↓, 20,   toxicity↑, 4,   toxicity↝, 12,   toxicity∅, 19,  

Infection & Microbiome ⓘ

Bacteria↓, 8,   Sepsis↓, 1,  
Total Targets: 326

Scientific Paper Hit Count for: Dose, Dosage
49 Selenium
26 Magnetic Fields
18 Silver-NanoParticles
17 Vitamin C (Ascorbic Acid)
16 Curcumin
14 Apigenin (mainly Parsley)
14 Propolis -bee glue
14 Hydrogen Gas
13 Resveratrol
10 Chemotherapy
10 Radiotherapy/Radiation
10 Sulforaphane (mainly Broccoli)
9 EGCG (Epigallocatechin Gallate)
8 Lycopene
7 Baicalein
7 Citric Acid
7 Ellagic acid
7 Silymarin (Milk Thistle) silibinin
7 Whole Body Vibration
6 Melatonin
6 Copper and Cu NanoParticlex
6 Dichloroacetate
6 Exercise
6 SonoDynamic Therapy UltraSound
6 Phenethyl isothiocyanate
5 Alpha-Lipoic-Acid
5 Boron
5 Hydroxycinnamic-acid
5 Magnetic Field Rotating
5 Phenylbutyrate
5 chitosan
5 Rosmarinic acid
5 Vitamin D3
5 VitK3,menadione
4 Allicin (mainly Garlic)
4 Metformin
4 Astaxanthin
4 Berberine
4 Boswellia (frankincense)
4 Caffeic acid
4 Capsaicin
4 Coenzyme Q10
4 Oxygen, Hyperbaric
4 diet FMD Fasting Mimicking Diet
4 Shilajit/Fulvic Acid
4 nicotinamide adenine dinucleotide
4 Propyl gallate
4 Thymoquinone
3 Ashwagandha(Withaferin A)
3 Disulfiram
3 Fisetin
3 Honokiol
3 metronomic chemo
3 Methylsulfonylmethane
3 Piperlongumine
3 Shikonin
3 Urolithin
3 Vitamin B1/Thiamine
3 Vitamin E
3 Vitamin K2
2 Anti-oxidants
2 Artemisinin
2 Betulinic acid
2 Chrysin
2 doxorubicin
2 diet Plant based
2 immunotherapy
2 Folic Acid
2 Gambogic Acid
2 Potassium
2 Luteolin
2 capecitabine
2 Iron
2 Silicic Acid
2 Glucose
2 Vitamin B5,Pantothenic Acid
1 Cisplatin
1 Acetyl-l-carnitine
1 Aromatherapy
1 Baicalin
1 beta-carotene(VitA)
1 Bicalutamide
1 Bortezomib
1 urea
1 Choline
1 Crocetin
1 CUSP9
1 diet Ketogenic
1 Zinc
1 Ferulic acid
1 Fenbendazole
1 Gallic acid
1 Garcinol
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 HydroxyCitric Acid
1 Huperzine A/Huperzia serrata
1 itraconazole
1 Juglone
1 MCToil
1 magnetic nanoparticles
1 Mushroom Lion’s Mane
1 Naringin
1 Nimbolide
1 Oleuropein
1 Hyperthermia
1 Phosphatidylserine
1 Pterostilbene
1 Quercetin
1 Radio Frequency
1 salinomycin
1 Calcium
1 irinotecan
1 Spermidine
1 Taurine
1 Ursolic acid
1 Vitamin B6,pyridoxine
1 Vitamin B12
1 Transarterial Chemoembolization
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1114  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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