Database Query Results : , , chemoR

chemoR, chemoresistance: Click to Expand ⟱
Source:
Type:
Chemoresistance refers to the ability of cancer cells to resist the effects of chemotherapy drugs, rendering treatments less effective or even ineffective. This resistance can be intrinsic (present before treatment) or acquired (developing during treatment) and poses a significant challenge in cancer therapy.

Eight recognized mechanisms underlying chemoresistance:
1.tumor heterogeneity;
2.inactivation of drugs (cytochrome P450, glutathione-S-transferase (GST), uridine diphospho-glucuronosyltransferase (UGT) superfamily);
3.overexpression of drug targets (EGFR and its downstream signaling targets);
4.efflux pump overexpression (MDR or P-gp, MRP1, ABCG2);
5.DNA damage repair;
6.evasion of cell death mediated by Bcl-2, Akt, NF-κB and STAT;
7.EMT favored by overexpression of TGF-β, FAK VEGF; and
8.epigenetic changes.
Scientific Papers found: Click to Expand⟱
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
4741- Se,    Selenium in Oncological Intervention
- Review, Var, NA
Risk↓, *other↝, Risk↓, AntiTum↑, chemoR↓, chemoP↑,
1509- SFN,    Combination therapy in combating cancer
- Review, NA, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, eff↑, PSA↓, P53↑, Hif1a↓, CAIX↓, chemoR↓, 5HT↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Fenton↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

CAIX↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Bax:Bcl2↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   FOXO4↑, 1,   HH↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   chemoR↓, 3,   ChemoSen↑, 1,   eff↑, 4,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

PSA↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 2,   Risk↓, 2,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   H2O2↑, 1,   HO-1↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death ⓘ

JNK↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

CardioT↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: chemoR, chemoresistance
1 Rosmarinic acid
1 Selenium
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1118  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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