Database Query Results : , , NADH:NAD

NADH:NAD, NADH:NAD+ ratio: Click to Expand ⟱
Source:
Type:
The ratio between NADH and NAD⁺ is a key indicator of a cell’s metabolic state.

• In many cancers, changes in this ratio may indicate increased reliance on glycolysis or alterations in mitochondrial function.
• Some studies have suggested that abnormal NADH metabolism or shifts in the NADH/NAD⁺ ratio can be correlated with tumor aggressiveness or response to therapy.
• For example, in certain cancers, a higher NADH/NAD⁺ ratio may be associated with more aggressive behavior, resistance to apoptosis, or poor prognosis.

A shift toward a higher NADH/NAD⁺ ratio can potentially impair these regulatory pathways, diminishing the cell’s capacity to respond to or repair damage from elevated ROS levels.
-A high NADH/NAD⁺ ratio can lead to increased ROS production, particularly through mitochondrial electron leakage.
Scientific Papers found: Click to Expand⟱
1869- DCA,    Dichloroacetate induces autophagy in colorectal cancer cells and tumours
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29
LC3II↑, ROS↑, mTOR↓, MCT1↓, NADH:NAD↓, NAD↑, TumAuto↑, lactateProd↓, LDH↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

lactateProd↓, 1,   LDH↑, 1,   NAD↑, 1,   NADH:NAD↓, 1,  

Cell Death ⓘ

MCT1↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  

Clinical Biomarkers ⓘ

LDH↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

H2O2↓, 1,   HO-1↑, 1,   mt-lipid-P↓, 1,   MDA↓, 1,   Mets↝, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   NADH:NAD↑, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Cyt‑c∅, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,   GSK‐3β↓, 1,  

Migration ⓘ

AntiAg↑, 1,   MMP9↓, 1,  

Barriers & Transport ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   p65↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 3,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,  

Functional Outcomes ⓘ

motorD↑, 1,   neuroP↑, 1,  
Total Targets: 35

Scientific Paper Hit Count for: NADH:NAD, NADH:NAD+ ratio
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1121  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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