Database Query Results : , , pax

pax, paxillin: Click to Expand ⟱
Source:
Type:
Paxillin is a multi-domain adaptor protein localized to focal adhesions that plays a critical role in integrin‐mediated signal transduction, cytoskeletal reorganization, and cellular motility.

Not only the overall expression levels, but also the phosphorylation state of paxillin (e.g., at tyrosine residues) is crucial. Abnormal phosphorylation can alter its interactions and downstream signaling, further enhancing cancer cell motility and survival.

Paxillin is frequently upregulated or aberrantly activated in various cancers. High expression and/or abnormal phosphorylation status of paxillin tends to correlate with increased tumor aggressiveness, enhanced metastatic potential, and generally poorer prognosis.
Scientific Papers found: Click to Expand⟱
1517- CAP,    Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
- in-vitro, Bladder, TSGH8301 - in-vitro, CRC, T24
ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1/CCND1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ENOX2↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↓, 2,  

Cell Death ⓘ

Bak↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   Casp3↑, 1,  

DNA Damage & Repair ⓘ

ac‑P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   p‑RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   p‑FAK↓, 1,   N-cadherin↓, 1,   p‑pax↓, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 2,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: pax, paxillin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1124  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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