Database Query Results : , , CRM

CRM, Calorie restriction mimetics (CRMs): Click to Expand ⟱
Source:
Type:
Calorie restriction mimetics (CRMs) are compounds that appear to mimic some of the biochemical effects of caloric restriction without the need to actually reduce caloric intake.

-Resveratrol:Known for activating sirtuins (e.g., SIRT1)
-Curcumin
-Quercetin
-EGCG
-Spermidine
-Fisetin
-Berberine
-Pterostilbene
-Hydroxytyrosol
-Sulforaphane
-Cinnamaldehyde
-Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)
-Alpha-Ketoglutarate (AKG)
-Rapamycin (Sirolimus
Scientific Papers found: Click to Expand⟱
1535- Ba,    Baicalein May Act as a Caloric Restriction Mimetic Candidate to Improve the Antioxidant Profile in a Natural Rodent Model of Aging
- in-vivo, Nor, NA
*antiOx↑, *ROS∅, *CRM↑,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3924- PTS,    Effect of resveratrol and pterostilbene on aging and longevity
- Review, AD, NA - Review, Stroke, NA
*antiOx↓, *ROS↑, *SOD↑, *GSH↑, *NRF2↑, *MDA↓, *HNE↓, *Inflam↓, *MAPK↓, *IL6↓, *TNF-α↓, *HO-1↑, *cardioP↑, *neuroP↑, *CRM↑, *NLRP3↓,
4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↓, 1,   ROS↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 1,   CRM↑, 3,   lipoGen↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   TumCG↓, 2,   TumCG⇅, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   eff↑, 4,   RadioS↑, 2,  

Functional Outcomes ⓘ

cardioP↑, 2,   cognitive↑, 1,   OS↑, 1,   toxicity∅, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 1,   GSH↑, 2,   GSTs↑, 1,   HNE↓, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 2,   NOX4↓, 1,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 1,   ROS∅, 1,   SOD↑, 2,   TAC↑, 1,  

Mitochondria & Bioenergetics ⓘ

OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

CRM↑, 3,  

Cell Death ⓘ

iNOS↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   STAT3↓, 1,  

Migration ⓘ

VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   IL1↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose⇅, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   creat↓, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 2,   RenoP↑, 1,  
Total Targets: 42

Scientific Paper Hit Count for: CRM, Calorie restriction mimetics (CRMs)
1 Baicalein
1 diet Short Term Fasting
1 diet FMD Fasting Mimicking Diet
1 HydroxyCitric Acid
1 Lycopene
1 Pterostilbene
1 Spermidine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1128  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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