Database Query Results : , , CYP1A2

CYP1A2, CYP1A2: Click to Expand ⟱
Source:
Type:
CYP1A2, cytochrome P450 enzyme
– CYP1A2 contributes to the metabolism of xenobiotics and can bioactivate pro-carcinogens into DNA-damaging compounds.
Scientific Papers found: Click to Expand⟱
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, eff↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
2216- SK,    Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
- in-vivo, Nor, NA
*NRF2↑, *AhR↑, *CYP1A1↑, *CYP1A2↑, *CYP2C6↑, *CYP2D1↑, *CYP3A2↑, *NQO1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx⇅, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GSH↓, 2,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 1,   OCR↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

CYP3A4↓, 2,   FASN↓, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-xL↓, 1,   Casp↑, 1,   Cyt‑c↑, 1,   DR4↑, 1,   DR5↑, 1,   Fas↑, 2,   JNK↑, 1,   MAPK↓, 1,   p27↑, 1,   survivin↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 2,   IGF-1↓, 1,   PI3K↓, 1,   TOP1↓, 1,   TOP2↓, 1,  

Migration ⓘ

FAK↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMP1↓, 1,   MMP9↓, 1,   MMPs↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 2,   Twist↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 2,   Hif1a↓, 2,   VEGF↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 3,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   CYP1A2↓, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 1,   Dose↓, 1,   Dose↝, 2,   Dose∅, 1,   eff↑, 1,   Half-Life∅, 1,   P450↓, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 2,   HER2/EBBR2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   chemoP↑, 1,   Risk↓, 1,  
Total Targets: 76

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   CYP1A1↑, 1,   GPx1↑, 1,   GSR↑, 1,   GSTA1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis ⓘ

CYP2C6↑, 1,   CYP3A2↑, 1,  

Cell Death ⓘ

AhR↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,  

Migration ⓘ

CYP2D1↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   CYP1A2↑, 1,   Dose↝, 2,   Half-Life↝, 1,  

Functional Outcomes ⓘ

toxicity↝, 1,  
Total Targets: 25

Scientific Paper Hit Count for: CYP1A2, CYP1A2
1 Apigenin (mainly Parsley)
1 Luteolin
1 Phenethyl isothiocyanate
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1129  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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