Database Query Results : , , SREBP2

SREBP2, Sterol Regulatory Element-Binding Protein 2: Click to Expand ⟱
Source:
Type:
Sterol Regulatory Element-Binding Protein 2 (SREBP-2)
SREBP-2 is a key transcription factor that primarily regulates cholesterol biosynthesis and uptake. In recent years, its dysregulation has been linked to altered lipid metabolism within tumors, potentially affecting tumor growth, metastasis, and response to treatment.
– SREBP-2) is a pivotal transcriptional factor in cholesterol metabolism.
– SREBP-2 controls the transcription of genes involved in cholesterol biosynthesis and uptake (e.g., HMG-CoA reductase, LDL receptor).
– Cancer cells may upregulate SREBP-2 as part of metabolic rewiring to meet the demands of rapid proliferation.

– Elevated SREBP-2 expression has been observed in several tumor types, including prostate, breast, and hepatocellular carcinoma.
– High expression levels are sometimes associated with aggressive tumor phenotypes, increased proliferative capacity, and a higher incidence of metastasis.

• SREBP-2 plays a critical role in maintaining lipid homeostasis, and its dysregulation in cancer can contribute to tumor growth and aggressiveness.
• Elevated SREBP-2 expression is generally associated with enhanced tumor cell proliferation, increased risk of metastasis, and in some instances, a poorer prognosis.
Scientific Papers found: Click to Expand⟱
1539- Api,  LT,    Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells
- in-vitro, Liver, HepG2
SREBP2↓, eff↑, p‑MEK↓, p‑ERK↓,
4988- ATV,  Dipy,    Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin–Dipyridamole Combination Treatment in Melanoma Cell Lines
- in-vivo, Melanoma, NA
HMGCR↓, SREBP2↑, SREBP2↓, AntiAg↑,
4985- ATV,  Dipy,    Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin-Dipyridamole Combination Treatment in Melanoma Cell Lines
- in-vivo, Melanoma, SK-MEL-28 - in-vitro, BC, MDA-MB-435
HMG-CoA↓, SREBP2↓, eff↑, HMGCR⇅, ChemoSen↑,
2349- CAP,    The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease
- in-vivo, AD, NA
*TRPV1↑, *PKM2↓, *SREBP2↑, *memory↑,
3246- EGCG,    Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway
- in-vitro, Nor, NA
*MDA↓, *SOD↑, *SIRT1↑, *FOXO1↑, *SREBP2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

p‑MEK↓, 1,  

Core Metabolism/Glycolysis ⓘ

HMG-CoA↓, 1,   SREBP2↓, 3,   SREBP2↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   HMGCR↓, 1,   HMGCR⇅, 1,  

Migration ⓘ

AntiAg↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↑, 2,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

MDA↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   SREBP2↑, 1,  

Cell Death ⓘ

TRPV1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO1↑, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: SREBP2, Sterol Regulatory Element-Binding Protein 2
2 Atorvastatin
2 Dipyridamole
1 Apigenin (mainly Parsley)
1 Luteolin
1 Capsaicin
1 EGCG (Epigallocatechin Gallate)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1132  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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